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anti-PACSIN2 antibody :: Rabbit anti-Human, Mouse PACSIN2 Polyclonal Antibody

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Catalog # MBS7046486
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

PACSIN2, Polyclonal Antibody

Popular Item
Also Known As

PACSIN2 Antibody

Product Synonym Names
Protein kinase C and casein kinase substrate in neurons protein 2; Syndapin-2; Syndapin-II; PACSIN2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
486
OMIM
604960
3D Structure
ModBase 3D Structure for Q9UNF0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Protein kinase C and casein kinase substrate in neurons protein 2 protein (240-410AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10417 / sc-10415
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PACSIN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PACSIN2 antibody
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Applications Tested/Suitable for anti-PACSIN2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-PACSIN2 antibody
Western blot
All lanes: PACSIN2 antibody at 2.62 ug/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse lung tissue
Lane 3: 3T3 whole cell lysate
Lane 4: Hela whole cell lysate
Lane 5: HL60 whole cell lysate
Lane 6: HepG-2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56,52 kDa
Observed band size: 56 kDa

anti-PACSIN2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PACSIN2 antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7046486 at dilution 1:100
anti-PACSIN2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PACSIN2 antibody
Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7046486 at dilution 1:100
anti-PACSIN2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PACSIN2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,353 Da
NCBI Official Full Name
protein kinase C and casein kinase substrate in neurons protein 2 isoform A
NCBI Official Synonym Full Names
protein kinase C and casein kinase substrate in neurons 2
NCBI Official Symbol
PACSIN2  [Similar Products]
NCBI Official Synonym Symbols
SDPII
  [Similar Products]
NCBI Protein Information
protein kinase C and casein kinase substrate in neurons protein 2
UniProt Protein Name
Protein kinase C and casein kinase substrate in neurons protein 2
UniProt Synonym Protein Names
Syndapin-2; Syndapin-II
UniProt Gene Name
PACSIN2  [Similar Products]
UniProt Entry Name
PACN2_HUMAN
NCBI Summary for PACSIN2
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Comments for PACSIN2
PACSIN2: May play a role in vesicle formation and transport. Belongs to the PACSIN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q13.2-q13.33

Cellular Component: caveola; cytoplasm; extrinsic to membrane; focal adhesion; intracellular membrane-bound organelle; nucleoplasm; recycling endosome membrane

Molecular Function: identical protein binding; protein binding; transporter activity

Biological Process: cell projection morphogenesis; regulation of endocytosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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