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anti-PAPSS1 antibody :: Rabbit PAPSS1 Polyclonal Antibody

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Catalog # MBS9214988
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

PAPSS1, Polyclonal Antibody

Full Product Name

PAPSS1 Antibody (N-term K9)

Product Synonym Names
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPS synthase 1; PAPSS 1; Sulfurylase kinase 1; SK 1; SK1; Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; PAPSS1; ATPSK1; PAPSS
Antibody/Peptide Pairs
PAPSS1 peptide (MBS9224724) is used for blocking the activity of PAPSS1 antibody (MBS9214988)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
1-30
OMIM
603262
3D Structure
ModBase 3D Structure for O43252
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse)
Specificity
This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PAPSS1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PAPSS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAPSS1 antibody
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.
Product Categories/Family for anti-PAPSS1 antibody
Applications Tested/Suitable for anti-PAPSS1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PAPSS1 antibody
WB~~1:1000

Western Blot (WB) of anti-PAPSS1 antibody
Western blot analysis of PAPSS1 antibody (N-term K9) in CEM cell line lysates (35ug/lane). PAPSS1 (arrow) was detected using the purified Pab.
anti-PAPSS1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for PAPSS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70833
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Official Symbol
PAPSS1  [Similar Products]
NCBI Official Synonym Symbols
SK1; PAPSS; ATPSK1
  [Similar Products]
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Synonym Protein Names
Sulfurylase kinase 1; SK 1; SK1
UniProt Gene Name
PAPSS1  [Similar Products]
UniProt Synonym Gene Names
ATPSK1; PAPSS; PAPS synthase 1; PAPSS 1; SK 1; SK1; SAT  [Similar Products]
UniProt Entry Name
PAPS1_HUMAN
NCBI Summary for PAPSS1
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
UniProt Comments for PAPSS1
PAPSS1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Protein type: Nucleotide Metabolism - purine; Energy Metabolism - sulfur; Kinase, other; Other Amino Acids Metabolism - selenoamino acid; EC 2.7.7.4; EC 2.7.1.25

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytosol

Molecular Function: adenylylsulfate kinase activity; ATP binding; sulfate adenylyltransferase (ATP) activity; nucleotidyltransferase activity

Biological Process: sulfate assimilation; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; pathogenesis; phosphorylation; skeletal development; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process
Product References and Citations for anti-PAPSS1 antibody
Venkatachalam, K.V., IUBMB Life 55(1):1-11 (2003).
Xu, Z.H., et al., Biochem. Biophys. Res. Commun. 268(2):437-444 (2000).
Venkatachalam, K.V., et al., J. Biol. Chem. 273(30):19311-19320 (1998).
ul Haque, M.F., et al., Nat. Genet. 20(2):157-162 (1998).
Girard, J.P., et al., FASEB J. 12(7):603-612 (1998).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Products associated with anti-PAPSS1 antibody
 Reference Product  PubMed Publications
 PAPSS2 antibody  >12 publications with PAPSS1 and PAPSS2
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