NP_001230154.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,456 Da
NCBI Official Full Name
pescadillo homolog isoform 2
NCBI Official Synonym Full Names
pescadillo ribosomal biogenesis factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
pescadillo homolog
UniProt Protein Name
Pescadillo homolog
NCBI Summary for PES1
This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
UniProt Comments for PES1
PES1: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding; RNA binding
Biological Process: cell proliferation; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of cell cycle; ribosomal large subunit biogenesis and assembly; rRNA processing
Research Articles on PES1
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Products associated with anti-PES1 antibody
Diseases associated with anti-PES1 antibody
Organs/Tissues associated with anti-PES1 antibody
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