NP_001159583.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 150 kD Predicted: 150 kDa
NCBI Official Full Name
neuropathy target esterase isoform a
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 6
NCBI Official Synonym Symbols
NTE; sws; BNHS; LNMS; OMCS; SPG39; NTEMND; iPLA2delta [Similar Products]
NCBI Protein Information
neuropathy target esterase
UniProt Protein Name
Neuropathy target esterase
UniProt Synonym Protein Names
Patatin-like phospholipase domain-containing protein 6Curated
NCBI Summary for PNPLA6
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for PNPLA6
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Research Articles on PNPLA6
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Pathways associated with anti-PNPLA6 antibody
Diseases associated with anti-PNPLA6 antibody
Organs/Tissues associated with anti-PNPLA6 antibody
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