NP_001003931.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
poly
NCBI Official Synonym Full Names
poly(ADP-ribose) polymerase family member 3
NCBI Official Synonym Symbols
IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3 [Similar Products]
NCBI Protein Information
poly [ADP-ribose] polymerase 3
UniProt Protein Name
Poly [ADP-ribose] polymerase 3
UniProt Synonym Protein Names
ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3
UniProt Synonym Gene Names
UniProt Entry Name
PARP3_HUMAN
NCBI Summary for PARP3
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for PARP3
PARP3: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.4.2.30; DNA repair, damage; Transferase
Chromosomal Location of Human Ortholog: 3p21.2
Cellular Component: centriole; cytoplasm; nucleus
Molecular Function: catalytic activity; DNA ligase (ATP) activity; NAD+ ADP-ribosyltransferase activity
Biological Process: DNA ligation during DNA repair; DNA repair; double-strand break repair; lagging strand elongation; positive regulation of DNA ligation; protein amino acid ADP-ribosylation; telomere maintenance
Research Articles on PARP3
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Products associated with anti-PARP3 antibody
Pathways associated with anti-PARP3 antibody
Diseases associated with anti-PARP3 antibody
Organs/Tissues associated with anti-PARP3 antibody
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