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anti-PARP3 antibody :: Rabbit anti-Human, Mouse Poly [ADP-ribose] polymerase 3 Polyclonal Antibody

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Catalog # MBS1494765
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Poly [ADP-ribose] polymerase 3 (PARP3), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Poly [ADP-ribose] polymerase 3 polyclonal Antibody(PARP3)

Product Synonym Names
PARP-3; hPARP-3; ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3; PARP3; ADPRT3; ADPRTL3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607726
3D Structure
ModBase 3D Structure for Q9Y6F1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Poly [ADP-ribose] polymerase 3 protein (294-533aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30625 / sc-130838 / sc-133887
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PARP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PARP3 antibody
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Applications Tested/Suitable for anti-PARP3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PARP3 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-PARP3 antibody
All lanes: Poly [ADP-ribose] polymerase 3 antibody at 2ug/ml+mouse heart tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 60kDa
Observed band size: 60kDa

anti-PARP3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PARP3 antibody
Immunohistochemistry of paraffin-embedded human kidney using MBS1494765 at dilution 1:100
anti-PARP3 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PARP3 antibody
Immunofluorescent analysis of Hela cells cells using MBS1494765 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PARP3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PARP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,846 Da
NCBI Official Full Name
poly
NCBI Official Synonym Full Names
poly(ADP-ribose) polymerase family member 3
NCBI Official Symbol
PARP3  [Similar Products]
NCBI Official Synonym Symbols
IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3
  [Similar Products]
NCBI Protein Information
poly [ADP-ribose] polymerase 3
UniProt Protein Name
Poly [ADP-ribose] polymerase 3
UniProt Synonym Protein Names
ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3
UniProt Gene Name
PARP3  [Similar Products]
UniProt Synonym Gene Names
ADPRT3; ADPRTL3; PARP-3; hPARP-3; ARTD3; ADPRT-3; pADPRT-3  [Similar Products]
UniProt Entry Name
PARP3_HUMAN
NCBI Summary for PARP3
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for PARP3
PARP3: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.2.30; DNA repair, damage; Transferase

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: centriole; cytoplasm; nucleus

Molecular Function: catalytic activity; DNA ligase (ATP) activity; NAD+ ADP-ribosyltransferase activity

Biological Process: DNA ligation during DNA repair; DNA repair; double-strand break repair; lagging strand elongation; positive regulation of DNA ligation; protein amino acid ADP-ribosylation; telomere maintenance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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