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anti-PRKD1 antibody :: Rabbit anti-Human, Mouse PRKD1 Polyclonal Antibody

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Catalog # MBS9404610
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

PRKD1, Polyclonal Antibody

Popular Item
Also Known As

PRKD1 Antibody

Product Synonym Names
PKD; PKCM; PRKCM; PKC-MU
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
912
OMIM
605435
3D Structure
ModBase 3D Structure for Q15139
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total PRKD1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
3.3 mg/ml (lot specific)
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to residues near the C terminal of human protein kinase D1
Target Name
PRKD1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-PRKD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PRKD1 antibody
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion.
Product Categories/Family for anti-PRKD1 antibody
Applications Tested/Suitable for anti-PRKD1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PRKD1 antibody
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Testing Data of anti-PRKD1 antibody
Gel: 6%SDS-PAGE Lysates (from left to right): 293T and NIH/3T3 cell Amount of lysate: 40ug per lane Primary antibody: 1/550 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds
anti-PRKD1 antibody Testing Data image
Immunohistochemistry (IHC) of anti-PRKD1 antibody
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/40.
anti-PRKD1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PRKD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102kd
NCBI Official Full Name
serine/threonine-protein kinase D1
NCBI Official Synonym Full Names
protein kinase D1
NCBI Official Symbol
PRKD1  [Similar Products]
NCBI Official Synonym Symbols
PKD; PKCM; PRKCM; PKC-MU
  [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase D1
UniProt Protein Name
Serine/threonine-protein kinase D1
UniProt Synonym Protein Names
Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu
UniProt Gene Name
PRKD1  [Similar Products]
UniProt Synonym Gene Names
PKD; PKD1; PRKCM  [Similar Products]
UniProt Entry Name
KPCD1_HUMAN
NCBI Summary for PRKD1
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]
UniProt Comments for PRKD1
PRKD1: a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A

Protein type: Protein kinase, CAMK; Motility/polarity/chemotaxis; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Autophagy; CAMK group; PKD family

Chromosomal Location of Human Ortholog: 14q11

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; intercellular junction; cell cortex; trans-Golgi network; nucleus; cytosol

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ATP binding

Biological Process: integrin-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; sphingolipid metabolic process; sphingolipid biosynthetic process; apoptosis; negative regulation of endocytosis; protein amino acid autophosphorylation; positive regulation of blood vessel endothelial cell migration; activation of CREB transcription factor; signal transduction; positive regulation of peptidyl-serine phosphorylation; Golgi vesicle transport; activation of NF-kappaB transcription factor; cell proliferation; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; peptidyl-serine phosphorylation; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; vascular endothelial growth factor receptor signaling pathway; inflammatory response; Golgi organization and biogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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