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anti-PRSS2 antibody :: Rabbit anti-Human, Mouse PRSS2 Polyclonal Antibody

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Catalog # MBS9128655
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Western Blot (WB)
Product Name

PRSS2, Polyclonal Antibody

Popular Item
Also Known As

PRSS2 Polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS9128655 COA
Immunogen Sequence Length
247
OMIM
601564
3D Structure
ModBase 3D Structure for P07478
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant Protein
Synonyms
TRY2; TRY8; TRYP2
Immunogen
Recombinant protein of human PRSS2
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-PRSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PRSS2 antibody
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
Applications Tested/Suitable for anti-PRSS2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PRSS2 antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:200

Western Blot (WB) of anti-PRSS2 antibody
Western blot analysis of extracts of various cell lines, using PRSS2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-PRSS2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for PRSS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
26kDa
NCBI Official Full Name
trypsin-2 isoform 2 preproprotein
NCBI Official Synonym Full Names
protease, serine, 2 (trypsin 2)
NCBI Official Symbol
PRSS2  [Similar Products]
NCBI Official Synonym Symbols
TRY2; TRY8; TRYP2
  [Similar Products]
NCBI Protein Information
trypsin-2
UniProt Protein Name
Trypsin-2
UniProt Synonym Protein Names
Anionic trypsinogen; Serine protease 2; Trypsin II
Protein Family
UniProt Gene Name
PRSS2  [Similar Products]
UniProt Synonym Gene Names
TRY2; TRYP2  [Similar Products]
UniProt Entry Name
TRY2_HUMAN
NCBI Summary for PRSS2
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
UniProt Comments for PRSS2
trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family.

Protein type: Calcium-binding; Cell adhesion; EC 3.4.21.4; Secreted, signal peptide; Secreted; Extracellular matrix; Protease

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; digestion; innate immune response; proteolysis; positive regulation of cell growth

Disease: Pancreatitis, Hereditary
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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