AAH01772.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,579 Da
NCBI Official Full Name
QARS protein, partial
NCBI Official Synonym Full Names
glutaminyl-tRNA synthetase
NCBI Protein Information
glutamine--tRNA ligase
UniProt Protein Name
Glutamine--tRNA ligase
UniProt Synonym Protein Names
Glutaminyl-tRNA synthetase; GlnRS
UniProt Synonym Gene Names
NCBI Summary for QARS
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for QARS
Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866).
Research Articles on QARS
Precautions
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Disclaimer
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Pathways associated with anti-QARS antibody
Diseases associated with anti-QARS antibody
Organs/Tissues associated with anti-QARS antibody
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