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anti-RASA4 antibody :: Rabbit anti-Human, Mouse RASA4 Polyclonal Antibody

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Catalog # MBS9610121
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

RASA4, Polyclonal Antibody

Popular Item
Full Product Name

RASA4 Antibody

Product Synonym Names
Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; GTPase activating protein like; KIAA0538; MGC131890; Ras GTPase activating protein 4; RAS p21 protein activator 4; RasGAP activating like protein 2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43374
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
RASA4 antibody detects endogenous levels of total RASA4
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human RASA4
Subcellular Location
Cytoplasm; Cytosol. Cell Membrane; Peripheral Membrane Protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Tissue Specificity
Widely expressed.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-RASA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RASA4 antibody
Function: Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Similarity: The PH domain does not bind phosphatidylinositol 4, 5-bisphosphate or phosphatidylinositol 3, 4, 5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
Applications Tested/Suitable for anti-RASA4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RASA4 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-RASA4 antibody
Western blot analysis of RASA4 using RAW264.7 whole cell lysates
anti-RASA4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for RASA4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 90 kDa
Predicted: 91 kDa
NCBI Official Full Name
ras GTPase-activating protein 4 isoform 2
NCBI Official Synonym Full Names
RAS p21 protein activator 4
NCBI Official Symbol
RASA4  [Similar Products]
NCBI Official Synonym Symbols
GAPL; CAPRI
  [Similar Products]
NCBI Protein Information
ras GTPase-activating protein 4
UniProt Protein Name
Ras GTPase-activating protein 4
UniProt Synonym Protein Names
Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2
UniProt Gene Name
RASA4  [Similar Products]
UniProt Synonym Gene Names
CAPRI; GAPL; KIAA0538  [Similar Products]
NCBI Summary for RASA4
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for RASA4
Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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