• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-REN antibody :: Rabbit anti-Human, Mouse REN Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS7049591
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

REN, Polyclonal Antibody

Popular Item
Full Product Name

REN Antibody

Product Synonym Names
Renin; Angiotensinogenase; REN
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
3D Structure
ModBase 3D Structure for P00797
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Renin protein (229-398AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27318 / sc-22752
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-REN antibody
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Applications Tested/Suitable for anti-REN antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-REN antibody
WB: 1: 2000-1: 5000
IF: 1: 50-1: 200

Western Blot (WB) of anti-REN antibody
Western Blot
Positive WB detected in:Mouse heart tissue,Mouse spleen tissue,Mouse lung tissue,Mouse stomach tissue
All lanes: REN antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46,45 kDa
Observed band size: 46,29 kDa

anti-REN antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-REN antibody
Immunofluorescent analysis of HepG2 cells using MBS7049591 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-REN antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,726 Da
NCBI Official Full Name
renin preproprotein
NCBI Official Synonym Full Names
renin
NCBI Official Symbol
NCBI Official Synonym Symbols
HNFJ2
  [Similar Products]
NCBI Protein Information
renin
UniProt Protein Name
Renin
UniProt Synonym Protein Names
Angiotensinogenase
Protein Family
UniProt Gene Name
UniProt Entry Name
RENI_HUMAN
NCBI Summary for REN
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
UniProt Comments for REN
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.15; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular region; extracellular space; lysosome; plasma membrane

Molecular Function: aspartic-type endopeptidase activity; peptidase activity; receptor binding

Biological Process: angiotensin maturation; kidney development; protein catabolic process; proteolysis; regulation of blood pressure; regulation of MAPKKK cascade

Disease: Hyperuricemic Nephropathy, Familial Juvenile, 2; Renal Tubular Dysgenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000