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anti-RICTOR antibody :: Rabbit anti-Human, mouse RICTOR Polyclonal Antibody

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Catalog # MBS9213882
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

RICTOR, Polyclonal Antibody

Popular Item
Also Known As

Purified Rabbit Polyclonal Antibody (Pab)

Product Synonym Names
Rapamycin-insensitive companion of mTOR; AVO3 homolog; hAVO3; RICTOR {ECO:0000312|EMBL:EAW559801}
Antibody/Peptide Pairs
RICTOR peptide (MBS9226728) is used for blocking the activity of RICTOR antibody (MBS9213882)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
805-835
Immunogen Sequence Length
1,732
OMIM
609022
3D Structure
ModBase 3D Structure for Q6R327
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This RICTOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-835 amino acids from the Central region of human RICTOR.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-RICTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RICTOR antibody
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Applications Tested/Suitable for anti-RICTOR antibody
Western Blot (WB)
Application Notes for anti-RICTOR antibody
WB~~1:1000

Western Blot (WB) of anti-RICTOR antibody
RICTOR Antibody (Center) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the RICTOR antibody detected the RICTOR protein (arrow).
anti-RICTOR antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for RICTOR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
192218
NCBI Official Full Name
rapamycin-insensitive companion of mTOR isoform 1
NCBI Official Synonym Full Names
RPTOR independent companion of MTOR, complex 2
NCBI Official Symbol
RICTOR  [Similar Products]
NCBI Official Synonym Symbols
PIA; AVO3; hAVO3
  [Similar Products]
NCBI Protein Information
rapamycin-insensitive companion of mTOR
UniProt Protein Name
Rapamycin-insensitive companion of mTOR
UniProt Synonym Protein Names
AVO3 homolog; hAVO3
UniProt Gene Name
RICTOR  [Similar Products]
UniProt Synonym Gene Names
hAVO3  [Similar Products]
UniProt Entry Name
RICTR_HUMAN
NCBI Summary for RICTOR
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
UniProt Comments for RICTOR
RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Cell cycle regulation; Adaptor/scaffold; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: TORC2 complex; cytosol

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; TOR signaling pathway; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; T cell costimulation; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway
Product References and Citations for anti-RICTOR antibody
Pearce,L.R., Biochem. J. 405 (3), 513-522 (2007)
Yang,Q., Genes Dev. 20 (20), 2820-2832 (2006)
Jacinto,E., Cell 127 (1), 125-137 (2006)

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