NP_001269455.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 36 kDa Predicted: 36 kDa
NCBI Official Full Name
DNA-directed RNA polymerase III subunit RPC6 isoform 2
NCBI Official Synonym Full Names
RNA polymerase III subunit F
NCBI Official Synonym Symbols
NCBI Protein Information
DNA-directed RNA polymerase III subunit RPC6
UniProt Protein Name
DNA-directed RNA polymerase III subunit RPC6
UniProt Synonym Protein Names
DNA-directed RNA polymerase III subunit F; RNA polymerase III 39 kDa subunit; RPC39
UniProt Synonym Gene Names
NCBI Summary for RPC6
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for RPC6
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).
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Pathways associated with anti-RPC6 antibody
Organs/Tissues associated with anti-RPC6 antibody
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