NP_001135821.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,876 Da
NCBI Official Full Name
sodium channel subunit beta-4 isoform 3
NCBI Official Synonym Full Names
sodium voltage-gated channel beta subunit 4
NCBI Protein Information
sodium channel subunit beta-4
UniProt Protein Name
Sodium channel subunit beta-4
UniProt Entry Name
SCN4B_HUMAN
NCBI Summary for SCN4B
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for SCN4B
SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: intrinsic to plasma membrane; voltage-gated sodium channel complex
Molecular Function: sodium channel regulator activity; voltage-gated sodium channel activity
Biological Process: cardiac muscle contraction; regulation of postsynaptic membrane potential; sodium ion transport
Disease: Long Qt Syndrome 10
Research Articles on SCN4B
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Pathways associated with anti-SCN4B antibody
Diseases associated with anti-SCN4B antibody
Organs/Tissues associated with anti-SCN4B antibody
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