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anti-SELE antibody :: Rabbit anti-Human, Mouse SELE Polyclonal Antibody

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Catalog # MBS126671
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Product Name

SELE, Polyclonal Antibody

Popular Item
Also Known As

SELE Polyclonal Antibody

Product Synonym Names
SELE; CD62EL; ELAM; ELAM1; ESEL; LECAM2; E-selectin; Leukocyte-endothelial cell adhesion molecule 2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
610
OMIM
131210
3D Structure
ModBase 3D Structure for P16581
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Species
Human
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human SELE
Calculated Molecular Weight
67kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-SELE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SELE antibody
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq]
Product Categories/Family for anti-SELE antibody
Applications Tested/Suitable for anti-SELE antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SELE antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-SELE antibody
Western blot analysis of extracts of various cell lines, using SELE antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-SELE antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-SELE antibody
Immunohistochemistry of paraffin-embedded human breast using SELE Antibody at dilution of 1:100 (40x lens).
anti-SELE antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SELE antibody
Immunohistochemistry of paraffin-embedded human uterus using SELE Antibody at dilution of 1:100 (40x lens).
anti-SELE antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SELE antibody
Immunohistochemistry of paraffin-embedded human uterine cancer using SELE Antibody at dilution of 1:100 (40x lens).
anti-SELE antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-SELE antibody
Immunofluorescence analysis of MCF-7 cells using SELE antibody. Blue: DAPI for nuclear staining.
anti-SELE antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for SELE. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
610
NCBI Official Full Name
E-selectin
NCBI Official Synonym Full Names
selectin E
NCBI Official Symbol
NCBI Official Synonym Symbols
ELAM; ESEL; CD62E; ELAM1; LECAM2
  [Similar Products]
NCBI Protein Information
E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2
UniProt Protein Name
E-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD_antigen: CD62E
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ELAM1; ELAM-1; LECAM2  [Similar Products]
UniProt Entry Name
LYAM2_HUMAN
NCBI Summary for SELE
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for SELE
SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q25

Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane; coated pit; caveola; lipid raft

Molecular Function: protein binding; phospholipase binding; transmembrane receptor activity; sialic acid binding

Biological Process: heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; positive regulation of leukocyte migration; positive regulation of receptor internalization; regulation of inflammatory response; actin filament-based process; calcium-mediated signaling; response to lipopolysaccharide; blood coagulation; leukocyte tethering or rolling; inflammatory response; leukocyte migration; leukocyte migration during inflammatory response

Disease: Hypertension, Essential
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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