• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-SENP1 antibody :: Rabbit anti-Human, Mouse SENP1 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS7051445
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

SENP1, Polyclonal Antibody

Popular Item
Full Product Name

SENP1 Antibody

Product Synonym Names
Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SENP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AF149770 mRNA
3D Structure
ModBase 3D Structure for Q9P0U3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Sentrin-specific protease 1 protein (63-214AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46634 / sc-67074
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SENP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SENP1 antibody
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed: 25406032).
Applications Tested/Suitable for anti-SENP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SENP1 antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-SENP1 antibody
Western Blot
Positive WB detected in:Hela whole cell lysate,HL60 whole cell lysate,Jurkat whole cell lysate,Mouse heart tissue,Mouse brain tissue,Mouse spleen tissue,Mouse stomach tissue,Mouse skeletal muscle tissue
All lanes: SENP1 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 74 kDa
Observed band size: 74,50 kDa

anti-SENP1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-SENP1 antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7051445 at dilution of 1:100
anti-SENP1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SENP1 antibody
Immunofluorescent analysis of Hela cells using MBS7051445 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SENP1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SENP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,351 Da
NCBI Official Full Name
sentrin-specific protease 1
NCBI Official Synonym Full Names
SUMO1/sentrin specific peptidase 1
NCBI Official Symbol
SENP1  [Similar Products]
NCBI Official Synonym Symbols
SuPr-2
  [Similar Products]
NCBI Protein Information
sentrin-specific protease 1
UniProt Protein Name
Sentrin-specific protease 1
UniProt Synonym Protein Names
Sentrin/SUMO-specific protease SENP1
Protein Family
UniProt Gene Name
SENP1  [Similar Products]
UniProt Entry Name
SENP1_HUMAN
NCBI Summary for SENP1
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
UniProt Comments for SENP1
SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.68; Nuclear receptor co-regulator; Protease

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus

Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000