NP_036373
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,689 Da
NCBI Official Full Name
NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NCBI Official Synonym Full Names
sirtuin 5
NCBI Official Synonym Symbols
NCBI Protein Information
NAD-dependent protein deacylase sirtuin-5, mitochondrial; SIRT5; sir2-like 5; sirtuin type 5; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
UniProt Protein Name
NAD-dependent protein deacylase sirtuin-5, mitochondrial
UniProt Synonym Protein Names
Regulatory protein SIR2 homolog 5; SIR2-like protein 5
UniProt Entry Name
SIR5_HUMAN
NCBI Summary for SIRT5
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
UniProt Comments for SIRT5
SIRT5: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. Belongs to the sirtuin family. Class III subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 3.5.1.-; Deacetylase
Chromosomal Location of Human Ortholog: 6p23
Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space; cytosol; nucleus
Molecular Function: zinc ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: protein amino acid ADP-ribosylation; protein amino acid deacetylation; chromatin silencing
Research Articles on SIRT5
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Products associated with anti-SIRT5 antibody
Pathways associated with anti-SIRT5 antibody
Diseases associated with anti-SIRT5 antibody
Organs/Tissues associated with anti-SIRT5 antibody
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