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anti-SLC25A4 antibody :: Rabbit anti-Human, mouse SLC25A4 Polyclonal Antibody

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Catalog # MBS7006610
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

SLC25A4, Polyclonal Antibody

Popular Item
Also Known As

SLC25A4 Antibody

Product Synonym Names
ADP/ATP translocase 1; SLC25A4; ANT1; ADP; ATP carrier protein 1; ADP; ATP carrier protein; heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
298
OMIM
103220
3D Structure
ModBase 3D Structure for P12235
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, mouse
Purity/Purification
Affinity Purified
Form/Format
Liquid
Immunogen
Recombinant human ADP/ATP translocase 1 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9299 / sc-9300 / sc-11433
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SLC25A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC25A4 antibody
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
Applications Tested/Suitable for anti-SLC25A4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SLC25A4 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-SLC25A4 antibody
Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7006610 at dilution of 1:100
anti-SLC25A4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SLC25A4 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS7006610 at dilution of 1:100
anti-SLC25A4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SLC25A4 antibody
Immunofluorescence staining of PC3 cells with MBS7006610 at 1:266,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
anti-SLC25A4 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SLC25A4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,064 Da
NCBI Official Full Name
ADP/ATP translocase 1
NCBI Official Synonym Full Names
solute carrier family 25 member 4
NCBI Official Symbol
SLC25A4  [Similar Products]
NCBI Official Synonym Symbols
T1; ANT; AAC1; ANT1; PEO2; PEO3; ANT 1; PEOA2; MTDPS12
  [Similar Products]
NCBI Protein Information
ADP/ATP translocase 1
UniProt Protein Name
ADP/ATP translocase 1
UniProt Synonym Protein Names
ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
Protein Family
UniProt Gene Name
SLC25A4  [Similar Products]
UniProt Synonym Gene Names
ANT1; ANT 1  [Similar Products]
UniProt Entry Name
ADT1_HUMAN
NCBI Summary for SLC25A4
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
UniProt Comments for SLC25A4
SLC25A4: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Belongs to the mitochondrial carrier family.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; Transporter

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: integral to plasma membrane; mitochondrial inner membrane; mitochondrion; myelin sheath; nucleus

Molecular Function: adenine transmembrane transporter activity; protein binding; structural constituent of ribosome

Biological Process: adenine transport; apoptotic mitochondrial changes; energy reserve metabolic process; generation of precursor metabolites and energy; mitochondrial genome maintenance; regulation of insulin secretion; translation; transmembrane transport; transport; viral reproduction

Disease: Mitochondrial Dna Depletion Syndrome 12 (cardiomyopathic Type); Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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