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anti-SPDEF antibody :: Rabbit anti-Human, Mouse SPDEF Polyclonal Antibody

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Catalog # MBS7049204
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

SPDEF, Polyclonal Antibody

Popular Item
Also Known As

SPDEF Antibody

Product Synonym Names
SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor; SPDEF; PDEF; PSE
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7049204 Technical Datasheet
Immunogen Sequence Length
319
OMIM
AB031549 mRNA
3D Structure
ModBase 3D Structure for O95238
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human SAM pointed domain-containing Ets transcription factor protein (145-247AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46446 / sc-46445 / sc-46443 / sc-67022
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SPDEF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SPDEF antibody
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
Applications Tested/Suitable for anti-SPDEF antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SPDEF antibody
WB: 1: 1000-1: 5000
IHC: 1: 20-1: 200

Western Blot (WB) of anti-SPDEF antibody
Western Blot
Positive WB detected in:Mouse brain tissue
All lanes: SPDEF antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38,36 kDa
Observed band size: 38 kDa

anti-SPDEF antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-SPDEF antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7049204 at dilution of 1:100
anti-SPDEF antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SPDEF antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7049204 at dilution of 1:100
anti-SPDEF antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SPDEF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,715 Da
NCBI Official Full Name
SAM pointed domain-containing Ets transcription factor isoform 2
NCBI Official Synonym Full Names
SAM pointed domain containing ETS transcription factor
NCBI Official Symbol
SPDEF  [Similar Products]
NCBI Official Synonym Symbols
PDEF; bA375E1.3
  [Similar Products]
NCBI Protein Information
SAM pointed domain-containing Ets transcription factor
UniProt Protein Name
SAM pointed domain-containing Ets transcription factor
UniProt Synonym Protein Names
Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor
UniProt Gene Name
SPDEF  [Similar Products]
UniProt Synonym Gene Names
PDEF; PSE; Prostate-specific Ets  [Similar Products]
UniProt Entry Name
SPDEF_HUMAN
NCBI Summary for SPDEF
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for SPDEF
SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleus

Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-SPDEF antibody
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