NP_689536.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
transcription factor Spi-C
NCBI Official Synonym Full Names
Spi-C transcription factor
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor Spi-C
UniProt Protein Name
Transcription factor Spi-C
UniProt Entry Name
SPIC_HUMAN
NCBI Summary for SPIC
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
UniProt Comments for SPIC
SPIC: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Belongs to the ETS family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component: nucleus
Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter
Research Articles on SPIC
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Products associated with anti-SPIC antibody
Diseases associated with anti-SPIC antibody
Organs/Tissues associated with anti-SPIC antibody
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