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anti-SUMF1 antibody :: Rabbit SUMF1 Polyclonal Antibody

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Catalog # MBS7604620
Unit / Price
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  0.1 mg  /  $290 +1 FREE 8GB USB
Western Blot
Product Name

SUMF1, Polyclonal Antibody

Popular Item
Full Product Name

SUMF1 Rabbit Polyclonal

Product Synonym Names
AAPA3037, FGE, sulfatase modifying factor 1, SUMF1, UNQ3037/PRO9852
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7604620 Technical Datasheet
OMIM
272200
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Human, Mouse; other species are not tested. Please decide the specificity by homology.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Immunogen
Sulfatase modifying factor 1
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SUMF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SUMF1 antibody
Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE.
Applications Tested/Suitable for anti-SUMF1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SUMF1 antibody
WB: 1:500-1:2000

Western Blot of anti-SUMF1 antibody
mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7604620 (SUMF1 antibody) at dilution of 1:1000
anti-SUMF1 antibody Western Blot (WB) image
NCBI/Uniprot data below describe general gene information for SUMF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46 kDa
NCBI Official Full Name
sulfatase-modifying factor 1 isoform 3
NCBI Official Synonym Full Names
sulfatase modifying factor 1
NCBI Official Symbol
SUMF1  [Similar Products]
NCBI Official Synonym Symbols
FGE; UNQ3037; AAPA3037
  [Similar Products]
NCBI Protein Information
sulfatase-modifying factor 1
UniProt Protein Name
Sulfatase-modifying factor 1
UniProt Synonym Protein Names
C-alpha-formylglycine-generating enzyme 1
UniProt Gene Name
SUMF1  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
SUMF1_HUMAN
NCBI Summary for SUMF1
This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
UniProt Comments for SUMF1
SUMF1: Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE. Defects in SUMF1 are the cause of multiple sulfatase deficiency (MSD). MSD is a clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay. Inheritance is autosomal recessive. Belongs to the sulfatase-modifying factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Secreted; EC 1.8.99.-; Endoplasmic reticulum; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p26.1

Cellular Component: endoplasmic reticulum lumen

Molecular Function: metal ion binding; oxidoreductase activity; protein homodimerization activity

Biological Process: glycosphingolipid metabolic process; post-translational protein modification

Disease: Multiple Sulfatase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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