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anti-TAPBP antibody :: Rabbit anti-Human, Mouse TAPBP Polyclonal Antibody

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Catalog # MBS9125502
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Product Name

TAPBP, Polyclonal Antibody

Popular Item
Full Product Name

TAPBP Polyclonal Antibody

Product Synonym Names
TPN; TAPA; TPSN; NGS17
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601962
3D Structure
ModBase 3D Structure for O15533
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Species
Human
Category
Primary antibody
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen
Recombinant protein of human TAPBP
Calculated Molecular Weight
47kDa
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-TAPBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TAPBP antibody
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
Product Categories/Family for anti-TAPBP antibody
Applications Tested/Suitable for anti-TAPBP antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TAPBP antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-TAPBP antibody
Western blot analysis of extracts of HT-29 cells, using TAPBP antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-TAPBP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TAPBP antibody
Immunohistochemistry of paraffin-embedded human stomach using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TAPBP antibody
Immunohistochemistry of paraffin-embedded rat testis using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TAPBP antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TAPBP antibody
Immunohistochemistry of paraffin-embedded mouse testis using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TAPBP antibody
Immunohistochemistry of paraffin-embedded mouse kidney using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TAPBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
448
NCBI Official Full Name
Tapasin
NCBI Official Synonym Full Names
TAP binding protein (tapasin)
NCBI Official Symbol
TAPBP  [Similar Products]
NCBI Official Synonym Symbols
TPN; TAPA; TPSN; NGS17
  [Similar Products]
NCBI Protein Information
tapasin; NGS-17; TAP-binding protein; TAP-associated protein
UniProt Protein Name
Tapasin
UniProt Synonym Protein Names
NGS-17; TAP-associated protein; TAP-binding protein
Protein Family
UniProt Gene Name
TAPBP  [Similar Products]
UniProt Synonym Gene Names
NGS17; TAPA; TPN; TPSN  [Similar Products]
UniProt Entry Name
TPSN_HUMAN
NCBI Summary for TAPBP
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for TAPBP
TAPBP: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; TAP complex; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; TAP1 binding; peptide antigen binding; MHC class I protein binding; unfolded protein binding; TAP2 binding; peptide antigen-transporting ATPase activity

Biological Process: peptide transport; antigen processing and presentation of peptide antigen via MHC class I; retrograde vesicle-mediated transport, Golgi to ER; peptide antigen stabilization; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein complex assembly; immune response; amide transport; antigen processing and presentation of endogenous peptide antigen via MHC class I

Disease: Bare Lymphocyte Syndrome, Type I
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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