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anti-TBX15 antibody :: Rabbit anti-Human, mouse TBX15 Polyclonal Antibody

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Catalog # MBS9210368
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

TBX15, Polyclonal Antibody

Popular Item
Full Product Name

TBX15 Antibody (N-term)

Product Synonym Names
T-box transcription factor TBX15; T-box protein 15; T-box transcription factor TBX14; T-box protein 14; TBX15; TBX14
Antibody/Peptide Pairs
TBX15 peptide (MBS9223522) is used for blocking the activity of TBX15 antibody (MBS9210368)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
47-73
OMIM
260660
3D Structure
ModBase 3D Structure for Q96SF7
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This TBX15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-73 amino acids from the N-terminal region of human TBX15.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.25 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-TBX15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TBX15 antibody
Probable transcriptional regulator involved in developmental processes.
Applications Tested/Suitable for anti-TBX15 antibody
Immunofluorescence (IF), ELISA (EIA), Western Blot (WB)
Application Notes for anti-TBX15 antibody
IF~~1:10~50
WB~~1:1000

Immunofluorescence (IF) of anti-TBX15 antibody
Fluorescent image of HUVEC cell stained with TBX15 Antibody (N-term). HUVEC cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with TBX15 primary antibody (1:25, 1 h at 37 degree). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree).TBX15 immunoreactivity is localized to Nucleus significantly.

anti-TBX15 antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-TBX15 antibody
TBX15 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TBX15 antibody detected the TBX15 protein (arrow).
anti-TBX15 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TBX15. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65757
NCBI Official Full Name
T-box transcription factor TBX15
NCBI Official Synonym Full Names
T-box 15
NCBI Official Symbol
TBX15  [Similar Products]
NCBI Official Synonym Symbols
TBX14
  [Similar Products]
NCBI Protein Information
T-box transcription factor TBX15
UniProt Protein Name
T-box transcription factor TBX15
UniProt Synonym Protein Names
T-box transcription factor TBX14; T-box protein 14
UniProt Gene Name
TBX15  [Similar Products]
UniProt Synonym Gene Names
TBX14; T-box protein 15; T-box protein 14  [Similar Products]
UniProt Entry Name
TBX15_HUMAN
NCBI Summary for TBX15
This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]
UniProt Comments for TBX15
TBX15: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Defects in TBX15 are the cause of Cousin syndrome (COUSS); also known as craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature. Cousin syndrome is defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p11.1

Molecular Function: protein homodimerization activity; protein heterodimerization activity; transcription factor activity

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; embryonic cranial skeleton morphogenesis

Disease: Cousin Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Products associated with anti-TBX15 antibody
 Reference Product  PubMed Publications
 PAX3 antibody  >2 publications with TBX15 and PAX3
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