NP_003212.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transcription factor AP-2-beta
NCBI Official Synonym Full Names
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor AP-2-beta
UniProt Protein Name
Transcription factor AP-2-beta
UniProt Synonym Protein Names
Activating enhancer-binding protein 2-beta
UniProt Synonym Gene Names
UniProt Entry Name
AP2B_HUMAN
NCBI Summary for TFAP2B
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
UniProt Comments for TFAP2B
AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; caspase inhibitor activity; chromatin binding; transcription factor activity; transcription corepressor activity
Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; skin development; hindlimb morphogenesis; positive regulation of transcription, DNA-dependent; response to lithium ion; regulation of BMP signaling pathway; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; calcium ion homeostasis; forelimb morphogenesis; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; regulation of cell differentiation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; sodium ion homeostasis; negative regulation of neuron apoptosis; phosphate ion homeostasis; kidney development; potassium ion homeostasis; response to drug; glucose metabolic process; renal water homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; negative regulation of apoptosis
Disease: Char Syndrome
Product References and Citations for anti-TFAP2B antibody
Li, X., et al. Genes Chromosomes Cancer 49(9):819-830(2010) Hotta, K., et al. J. Hum. Genet. (2010) In press : Ugi, S., et al. Obesity (Silver Spring) 18(7):1277-1282(2010) Nordquist, N., et al. Brain Res. 1305 SUPPL, S20-S26 (2009) : Lindgren, C.M., et al. PLoS Genet. 5 (6), E1000508 (2009) :
Research Articles on TFAP2B
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Products associated with anti-TFAP2B antibody
Diseases associated with anti-TFAP2B antibody
Organs/Tissues associated with anti-TFAP2B antibody
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