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anti-TFEB antibody :: Rabbit anti-Human, Mouse TFEB Polyclonal Antibody

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Catalog # MBS2538354
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

TFEB, Polyclonal Antibody

Popular Item
Full Product Name

TFEB Polyclonal Antibody

Product Synonym Names
TFEB; BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2538354 Technical Datasheet
OMIM
600744
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TFEB antibody
Background: TFEB (Transcription Factor EB) is a Protein Coding gene. Diseases associated with TFEB include Renal Cell Carcinoma, Papillary and Microphthalmia. Among its related pathways are Apoptosis and Autophagy and PI3K-AKT-mTOR signaling pathway and therapeutic opportunities. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MITF.
Product Categories/Family for anti-TFEB antibody
Applications Tested/Suitable for anti-TFEB antibody
WB, IHC-p, ELISA
Application Notes for anti-TFEB antibody
WB: 1:500-1:2000
IHC 1:100-1:300
ELISA 1:2000

Western Blot (WB) of anti-TFEB antibody
Western Blot analysis of Mouse lung, Mouse muscle using TFEB Polyclonal Antibody at dilution of 1:500.
anti-TFEB antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transcription factor EB isoform 2
NCBI Official Synonym Full Names
transcription factor EB
NCBI Official Symbol
NCBI Official Synonym Symbols
TCFEB; BHLHE35; ALPHATFEB
  [Similar Products]
NCBI Protein Information
transcription factor EB
UniProt Protein Name
Transcription factor EB
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 35; bHLHe35
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BHLHE35; bHLHe35  [Similar Products]
UniProt Entry Name
TFEB_HUMAN
UniProt Comments for TFEB
TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nucleus

Molecular Function: protein dimerization activity; transcription factor activity

Biological Process: adaptive immune response; autophagy; embryonic placenta development; humoral immune response; lysosome organization and biogenesis; positive regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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