NP_001094284.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,191 Da
NCBI Official Full Name
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1
NCBI Official Synonym Full Names
transmembrane protein 55B
NCBI Official Synonym Symbols
NCBI Protein Information
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
UniProt Protein Name
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
UniProt Synonym Protein Names
PtdIns-4,5-P2 4-Ptase I; Transmembrane protein 55B
UniProt Synonym Gene Names
UniProt Entry Name
TM55B_HUMAN
NCBI Summary for TMEM55B
TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
UniProt Comments for TMEM55B
TMEM55B: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 3.1.3.78; Hydrolase
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: integral to membrane; late endosome membrane; lysosomal membrane
Biological Process: phosphoinositide dephosphorylation
Research Articles on TMEM55B
Precautions
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Pathways associated with anti-TMEM55B antibody
Diseases associated with anti-TMEM55B antibody
Organs/Tissues associated with anti-TMEM55B antibody
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