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anti-TOX3 antibody :: Rabbit anti-Human, Mouse TOX3 Polyclonal Antibody

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Catalog # MBS7046650
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

TOX3, Polyclonal Antibody

Popular Item
Also Known As

TOX3 Antibody

Product Synonym Names
TOX high mobility group box family member 3; CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein; TOX3; CAGF9; TNRC9
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
576
OMIM
611416
3D Structure
ModBase 3D Structure for O15405
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human TOX high mobility group box family member 3 protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TOX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TOX3 antibody
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
Applications Tested/Suitable for anti-TOX3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Western Blot (WB) of anti-TOX3 antibody
Western blot
All lanes: TOX3 antibody at 9 ug/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse spleen tissue
Lane 3: Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 63 kDa
Observed band size: 63,24 kDa

anti-TOX3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TOX3 antibody
Immunohistochemistry of paraffin-embedded human brain tissue using MBS7046650 at dilution of 1:100
anti-TOX3 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TOX3 antibody
Immunofluorescent analysis of HepG-2 cells using MBS7046650 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TOX3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TOX3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,100 Da
NCBI Official Full Name
TOX high mobility group box family member 3 isoform 1
NCBI Official Synonym Full Names
TOX high mobility group box family member 3
NCBI Official Symbol
NCBI Official Synonym Symbols
CAGF9; TNRC9
  [Similar Products]
NCBI Protein Information
TOX high mobility group box family member 3
UniProt Protein Name
TOX high mobility group box family member 3
UniProt Synonym Protein Names
CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein
UniProt Gene Name
UniProt Synonym Gene Names
CAGF9; TNRC9  [Similar Products]
UniProt Entry Name
TOX3_HUMAN
NCBI Summary for TOX3
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
UniProt Comments for TOX3
TOX3: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q12.1

Molecular Function: chromatin binding; estrogen response element binding; phosphoprotein binding; protein binding; protein homodimerization activity

Biological Process: negative regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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