View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-TRPC6 antibody :: Rabbit anti-Human, Mouse TRPC6 Polyclonal Antibody Catalog # MBS9135093 (SPECIAL PROMOTION: Get FREE $5 Amazon gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) Unit / Price 0.02 mL / $210 +1 FREE 8GB USB 0.05 mL / $265 +1 FREE 8GB USB 0.1 mL / $355 +1 FREE 8GB USB 0.2 mL / $555 +1 FREE 8GB USB 5x0.2 mL / $2,275 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name TRPC6, Polyclonal Antibody Popular Item Full Product Name TRPC6 Polyclonal Antibody Product Synonym Names FSGS2; TRP6 Product Gene Name anti-TRPC6 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Immunogen Sequence QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLVPSPK SLFYLLLKLK KWISELFQGH KKGFQEDAEM NKINEEKKLG ILGSHEDLSK LSLDKKQVGH NKQPSIRSSE DFHLNSFNNP PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE KSQNTEDLAE LIRELGEKLS MEPNQEETNR OMIM AF080394 mRNA 3D Structure ModBase 3D Structure for Q9Y210 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse Purity/Purification Affinity Purification Immunogen Recombinant protein of human TRPC6 Immunogen Species Human Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Cellular Location Membrane, Multi-pass membrane protein Preparation and Storage Store at -20 degree C. Avoid freeze / thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-TRPC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-TRPC6 antibody The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). Product Categories/Family for anti-TRPC6 antibody Polyclonal Antibodies Applications Tested/Suitable for anti-TRPC6 antibody Western Blot (WB), Immunofluorescence (IF) Application Notes for anti-TRPC6 antibody WB: 1:500 - 1:2000IF: 1:50 - 1:200 TOP NCBI/Uniprot data below describe general gene information for TRPC6. It may not necessarily be applicable to this product. NCBI GI # 5730102 NCBI GeneID 7225 NCBI Accession # NP_004612.2 [Other Products] NCBI GenBank Nucleotide # NM_004621.5 [Other Products] UniProt Primary Accession # Q9Y210 [Other Products] UniProt Secondary Accession # Q52M59; Q9HCW3; Q9NQA8; Q9NQA9[Other Products] UniProt Related Accession # Q9Y210[Other Products] Molecular Weight 93kDa/100kDa/106kDa TOP NCBI Official Full Name short transient receptor potential channel 6 NCBI Official Synonym Full Names transient receptor potential cation channel subfamily C member 6 NCBI Official Symbol TRPC6 [Similar Products] NCBI Official Synonym Symbols TRP6; FSGS2 [Similar Products] NCBI Protein Information short transient receptor potential channel 6 UniProt Protein Name Short transient receptor potential channel 6 UniProt Synonym Protein Names Transient receptor protein 6; TRP-6 Protein Family Short transient receptor potential channel UniProt Gene Name TRPC6 [Similar Products] UniProt Synonym Gene Names TRP-6 [Similar Products] TOP NCBI Summary for TRPC6 The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] TOP UniProt Comments for TRPC6 Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. Research Articles on TRPC6 1. potential implications of transient receptor potential (TRP) channels in the pathogenesis of intestinal fibrosis, since they are known to act as cellular stress sensors/transducers affecting intracellular Ca(2+) homeostasis/dynamics, and are involved in a broad spectrum of cell pathophysiology including inflammation and tissue remodeling. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-TRPC6 antibody Reference Product PubMed Publications TRPC3 antibody >225 publications with TRPC6 and TRPC3 TRPC1 antibody >197 publications with TRPC6 and TRPC1 TRPC4 antibody >113 publications with TRPC6 and TRPC4 TRPC5 antibody >102 publications with TRPC6 and TRPC5 NPHS2 antibody >30 publications with TRPC6 and NPHS2 SRC antibody >18 publications with TRPC6 and SRC FYN antibody >8 publications with TRPC6 and FYN KIRREL antibody >2 publications with TRPC6 and KIRREL RNF24 antibody >1 publications with TRPC6 and RNF24 Pathways associated with anti-TRPC6 antibody Products by Pathway Pathway Diagram Axon Guidance Pathway antibodies Axon Guidance Pathway Diagram Developmental Biology Pathway antibodies Developmental Biology Pathway Diagram EPO Signaling Pathway antibodies EPO Signaling Pathway Diagram Effects Of PIP2 Hydrolysis Pathway antibodies Effects Of PIP2 Hydrolysis Pathway Diagram Elevation Of Cytosolic Ca2+ Levels Pathway antibodies Elevation Of Cytosolic Ca2+ Levels Pathway Diagram Endothelins Pathway antibodies Endothelins Pathway Diagram G Alpha (q) Signalling Events Pathway antibodies G Alpha (q) Signalling Events Pathway Diagram GPCR Downstream Signaling Pathway antibodies GPCR Downstream Signaling Pathway Diagram Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram Hemostasis Pathway antibodies Hemostasis Pathway Diagram Diseases associated with anti-TRPC6 antibody Disease Name Pubmed Publications Kidney Diseases Antibodies >97 publications with TRPC6 and Kidney Diseases Hypertension Antibodies >72 publications with TRPC6 and Hypertension Hypertrophy Antibodies >42 publications with TRPC6 and Hypertrophy Heart Diseases Antibodies >36 publications with TRPC6 and Heart Diseases Focal Segmental Glomerulosclerosis 2 Antibodies >31 publications with TRPC6 and Focal Segmental Glomerulosclerosis 2 Cardiomegaly Antibodies >21 publications with TRPC6 and Cardiomegaly Brain Diseases Antibodies >18 publications with TRPC6 and Brain Diseases Disease Susceptibility Antibodies >18 publications with TRPC6 and Disease Susceptibility Heart Failure Antibodies >16 publications with TRPC6 and Heart Failure Inflammation Antibodies >13 publications with TRPC6 and Inflammation Organs/Tissues associated with anti-TRPC6 antibody Organ/Tissue Name Pubmed Publications Vascular Antibodies >178 publications with TRPC6 and Vascular Kidney Antibodies >168 publications with TRPC6 and Kidney Brain Antibodies >82 publications with TRPC6 and Brain Heart Antibodies >76 publications with TRPC6 and Heart Lung Antibodies >42 publications with TRPC6 and Lung Eye Antibodies >13 publications with TRPC6 and Eye Prostate Antibodies >9 publications with TRPC6 and Prostate Trachea Antibodies >5 publications with TRPC6 and Trachea Placenta Antibodies >4 publications with TRPC6 and Placenta TOP © 2006-24 MyBioSource.com. 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