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anti-TSLP antibody :: Rabbit anti-Human, Mouse TSLP Polyclonal Antibody

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Catalog # MBS150203
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

TSLP, Polyclonal Antibody

Popular Item
Full Product Name

TSLP Antibody

Product Synonym Names
TSLP; Thymic stromal lymphopoietin; thymic stromal lymphopoietin
Antibody/Peptide Pairs
TSLP peptide (MBS152706) is used for blocking the activity of TSLP antibody (MBS150203)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607003
3D Structure
ModBase 3D Structure for Q969D9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
TSLP Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
TSLP antibody was raised against a 19 amino acid synthetic peptide from near the center of human TSLP.
The immunogen is located withing amino acids 40-90 of TSLP
Buffer
TSLP Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TSLP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-TSLP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSLP antibody
TSLP Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.
Applications Tested/Suitable for anti-TSLP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TSLP antibody
TSLP antibody can be used for detection of TSLP by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.

Positive Control:
1) Cat. No. MBS151677 - A20 Cell Lysate
2) Cat. No. MBS151732 - Human Brain Tissue Lysate
3) Cat. No. MBS154323 - Human Brain Tissue Slide

Western Blot (WB) of anti-TSLP antibody
Western blot analysis of TSLP in A-20 cell lysate with TSLP antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-TSLP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TSLP antibody
Immunohistochemistry of TSLP in human brain tissue with TSLP antibody at 2.5 μg/mL.
anti-TSLP antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-TSLP antibody
Immunofluorescence of TSLP in Human Brain tissues with TSLP antibody at 20 μg/mL.
anti-TSLP antibody Immunofluorescence (IF) image
Immunofluorescence of anti-TSLP antibody
Immunofluorescence of TSLP in mouse brain tissue with TSLP antibody at 20 ug/ml.
anti-TSLP antibody Immunofluorescence image
Immunohistochemistry of anti-TSLP antibody
Immunohistochemistry of TSLP in human brain tissue with TSLP antibody at 2.5 ug/mL.
anti-TSLP antibody Immunohistochemistry (IHC) image
NCBI/Uniprot data below describe general gene information for TSLP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 17 kDa

Observed: 23 kDa
NCBI Official Full Name
thymic stromal lymphopoietin isoform 1
NCBI Official Synonym Full Names
thymic stromal lymphopoietin
NCBI Official Symbol
NCBI Protein Information
thymic stromal lymphopoietin
UniProt Protein Name
Thymic stromal lymphopoietin
UniProt Gene Name
UniProt Entry Name
TSLP_HUMAN
NCBI Summary for TSLP
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Comments for TSLP
TSLP: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q22.1

Cellular Component: extracellular space

Molecular Function: cytokine activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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