• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-TSC2 antibody :: Rabbit anti-Human, Mouse Tuberin / TSC2 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS241346
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

Tuberin / TSC2, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human Tuberin / TSC2

Product Synonym Names
Anti-Tuberin / TSC2 Antibody (C-Terminus) IHC-plus; TSC2; LAM; Tuberous sclerosis 2 protein; TSC4; Tuberin; Tuberous sclerosis 2; Human Tuberin; TSC2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1807
OMIM
phenotype 613254
3D Structure
ModBase 3D Structure for P49815
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
15 amino acid peptide from near the carboxy-terminus of human TSC2
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human TSC2.
Immunogen Type
Synthetic peptide
Immunogen
Tuberin / TSC2 antibody was raised against synthetic peptide from human TSC2.
Antigen Modification
C-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-TSC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSC2 antibody
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors.
Applications Tested/Suitable for anti-TSC2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TSC2 antibody
IHC-P (5 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TSC2 antibody
Anti-TSC2 / Tuberin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-TSC2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-TSC2 antibody
Western blot of TSC2 in L1210 cell lysate with TSC2 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
anti-TSC2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TSC2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,773 Da
NCBI Official Full Name
tuberin isoform 1
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
NCBI Official Synonym Symbols
LAM; TSC4; PPP1R160
  [Similar Products]
NCBI Protein Information
tuberin; tuberous sclerosis 2 protein; protein phosphatase 1, regulatory subunit 160
UniProt Protein Name
Tuberin
UniProt Synonym Protein Names
Tuberous sclerosis 2 protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
TSC2_HUMAN
NCBI Summary for TSC2
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for TSC2
TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described.

Protein type: Tumor suppressor; GAPs; Cell cycle regulation; Nuclear receptor co-regulator; GAPs, misc.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: TSC1-TSC2 complex; Golgi apparatus; growth cone; cytoskeleton; membrane; cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; caveola; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding

Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; negative regulation of Wnt receptor signaling pathway; regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; protein heterooligomerization; regulation of cell cycle; heart development; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; negative regulation of cell proliferation; protein localization; cell projection organization and biogenesis; positive chemotaxis; protein import into nucleus; regulation of endocytosis; acute-phase response; protein kinase B signaling cascade; cell cycle arrest; protein homooligomerization; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; negative regulation of TOR signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; endocytosis; vesicle-mediated transport; insulin-like growth factor receptor signaling pathway; glucose import; neural tube closure; insulin receptor signaling pathway; response to hypoxia; innate immune response; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of phosphoinositide 3-kinase cascade

Disease: Lymphangioleiomyomatosis; Tuberous Sclerosis 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000