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anti-USP30 antibody :: Rabbit anti-Human, mouse USP30 Polyclonal Antibody

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Catalog # MBS7001025
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

USP30, Polyclonal Antibody

Popular Item
Also Known As

USP30 Antibody

Product Synonym Names
Ubiquitin carboxyl-terminal hydrolase 30 (EC:3.4.19.121 Publication; USP30; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
486
OMIM
612492
3D Structure
ModBase 3D Structure for Q70CQ3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, mouse
Purity/Purification
Affinity Purified
Form/Format
Liquid
Immunogen
Recombinant human Ubiquitin carboxyl-terminal hydrolase 30 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109455
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-USP30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-USP30 antibody
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
Applications Tested/Suitable for anti-USP30 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-USP30 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-USP30 antibody
Western blot
All lanes: USP30 antibody at 7ug/ml+ Mouse lung tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 59 kDa
Observed band size: 59 kDa

anti-USP30 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-USP30 antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7001025 at dilution of 1:100
anti-USP30 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-USP30 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS7001025 at dilution of 1:100
anti-USP30 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for USP30. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,503 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 30 isoform 2
NCBI Official Synonym Full Names
ubiquitin specific peptidase 30
NCBI Official Symbol
USP30  [Similar Products]
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 30
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 30
UniProt Synonym Protein Names
Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
UniProt Gene Name
USP30  [Similar Products]
UniProt Synonym Gene Names
Ub-specific protease 30  [Similar Products]
UniProt Entry Name
UBP30_HUMAN
NCBI Summary for USP30
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
UniProt Comments for USP30
USP30: May participate in the maintenance of mitochondrial morphology. Belongs to the peptidase C19 family.

Protein type: EC 3.4.19.12; Protease; Membrane protein, integral; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: integral to membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: mitochondrial fusion; mitochondrion degradation; protein deubiquitination; ubiquitin-dependent protein catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-USP30 antibody
 Reference Product  PubMed Publications
 USP1 antibody  >1 publications with USP30 and USP1
Diseases associated with anti-USP30 antibody
Organs/Tissues associated with anti-USP30 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with USP30 and Brain
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