NP_001266282.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,983 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 45 isoform 2
NCBI Official Synonym Full Names
vacuolar protein sorting 45 homolog (S. cerevisiae)
NCBI Official Synonym Symbols
H1; SCN5; VSP45; VPS45A; VPS45B; VPS54A; VSP45A; H1VPS45 [Similar Products]
NCBI Protein Information
vacuolar protein sorting-associated protein 45
UniProt Protein Name
Vacuolar protein sorting-associated protein 45
UniProt Synonym Gene Names
UniProt Entry Name
VPS45_HUMAN
NCBI Summary for VPS45
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for VPS45
VPS45A: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Belongs to the STXBP/unc-18/SEC1 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component: endosome membrane; Golgi apparatus; Golgi membrane; integral to membrane
Molecular Function: protein binding
Biological Process: blood coagulation; intracellular protein transport; vesicle docking during exocytosis
Disease: Neutropenia, Severe Congenital, 5, Autosomal Recessive
Research Articles on VPS45
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Products associated with anti-VPS45 antibody
Pathways associated with anti-VPS45 antibody
Diseases associated with anti-VPS45 antibody
Organs/Tissues associated with anti-VPS45 antibody
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