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anti-DISP1 antibody :: Goat Dispatched homolog 1 Polyclonal Antibody

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Catalog # MBS420640
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Immunofluorescence (IF)
Product Name

Dispatched homolog 1 (DISP1), Polyclonal Antibody

Full Product Name

Goat anti-Dispatched homolog 1 Antibody

Product Synonym Names
DISP1; DISPA; MGC13130; MGC16796; DKFZP434I0428; dispatched A; DISP1; dispatched homolog 1; dispatched homolog 1 (Drosophila); FLJ43740; MGC104180; DISPA antibody; MGC13130 antibody; MGC16796 antibody; DKFZP434I0428 antibody; dispatched A antibody; DISP1 antibody; dispatched homolog 1 antibody; dispatched homolog 1 (Drosophila) antibody; FLJ43740 antibody; MGC104180 antibody; Dispatched homolog 1; Dispatched homolog 1
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
SELSGESLLI KTL
OMIM
607502
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-SELSGESLLIKTL, from the C Terminus of the protein sequence according to NP_116279.2.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-DISP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DISP1 antibody
Peptide ELISA (EIA), Immunofluorescence (IF)
Application Notes for anti-DISP1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave no signal but low background in Human Lung and A549 extracts at up to 1ug/ml.
Immunofluorescence: Cell membrane staining in cell line U87. These data corresponds to earlier findings in literature with different antibodies (Etheridge et al, Development.2010 Jan;137(1): 133-40; PMID: 20023168).

Immunofluorescence (IF) of anti-DISP1 antibody
(2.5ug/ml) staining of U87. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.
anti-DISP1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for DISP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
170,934 Da
NCBI Official Full Name
protein dispatched homolog 1
NCBI Official Synonym Full Names
dispatched RND transporter family member 1
NCBI Official Symbol
DISP1  [Similar Products]
NCBI Official Synonym Symbols
DISPA
  [Similar Products]
NCBI Protein Information
protein dispatched homolog 1
UniProt Protein Name
Protein dispatched homolog 1
Protein Family
UniProt Gene Name
DISP1  [Similar Products]
UniProt Synonym Gene Names
DISPA  [Similar Products]
UniProt Entry Name
DISP1_HUMAN
NCBI Summary for DISP1
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
UniProt Comments for DISP1
DISP1: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Belongs to the dispatched family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: integral to membrane

Molecular Function: hedgehog receptor activity; peptide transporter activity; protein binding

Biological Process: determination of left/right symmetry; dorsal/ventral pattern formation; embryonic pattern specification; patched ligand processing; peptide transport; smoothened signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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