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anti-Esr2 antibody :: Rabbit Estrogen Receptor beta Polyclonal Antibody

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Catalog # MBS534283
Unit / Price
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  0.05 mg  /  $745 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

Estrogen Receptor beta (Esr2), Polyclonal Antibody

Full Product Name

Estrogen Receptor beta antibody

Product Synonym Names
Polyclonal Estrogen Receptor beta; Anti-Estrogen Receptor beta; ER beta
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q59IV8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Non-Human Primate, Rat, Sheep
Specificity
Rat
Purity/Purification
Estrogen Receptor Beta antibody was purified by affinity chromatography.
Form/Format
Affinity purified IgG supplied in PBS with 1 mg/ml BSA and 0.05% NaN3.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Estrogen receptor beta antibody was raised in rabbit using a synthetic peptide corresponding to residues A(55) E P Q K S P W C E A R S L E H(70) of rat estrogen receptor beta as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-Esr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Esr2 antibody
Affinity purified Rabbit polyclonal Estrogen Receptor beta antibody
Applications Tested/Suitable for anti-Esr2 antibody
Gel Shift, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-Esr2 antibody
Gel Shift: 1-5 ul
ICC: 2-4 ug/ml
IF: 0.5 ug/ml
IHC-F: 1-2 ug/ml
IHC-P: 1-2 ug/ml
WB: 1-2 ug/ml

Immunohistochemistry (IHC) of anti-Esr2 antibody

anti-Esr2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Esr2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
63,322 Da[Similar Products]
NCBI Official Full Name
estrogen receptor beta
NCBI Official Synonym Full Names
estrogen receptor 2 (ER beta)
NCBI Official Symbol
NCBI Official Synonym Symbols
Erb2; ERbeta; ER-beta
  [Similar Products]
NCBI Protein Information
estrogen receptor beta
UniProt Protein Name
Estrogen receptor 2 beta, isoform CRA_a
UniProt Synonym Protein Names
Estrogen receptor 2 beta, isoform CRA_a
Protein Family
UniProt Gene Name
UniProt Entry Name
Q59IV8_RAT
NCBI Summary for Esr2
binds estrogen and mediates transcriptional activation [RGD, Feb 2006]
UniProt Comments for Esr2
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: neuron projection; mitochondrion; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium

Molecular Function: protein binding; peroxisome proliferator activated receptor binding; ligand-dependent nuclear receptor activity; estrogen receptor activity; enzyme binding; DNA binding; hormone binding; zinc ion binding; sequence-specific DNA binding; estrogen response element binding; steroid hormone receptor activity; drug binding; transcription factor activity; steroid binding

Biological Process: prostate gland development; hypothalamus development; behavioral fear response; estrogen receptor signaling pathway; negative regulation of smooth muscle cell proliferation; induction of apoptosis by hormones; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; negative regulation of transcription from RNA polymerase II promoter; amygdala development; uterus development; response to insecticide; response to organic cyclic substance; response to estradiol stimulus; negative regulation of cell proliferation; learning and/or memory; ovarian follicle development; regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; cerebellum development; female gonad development; negative regulation of epithelial cell proliferation; response to nutrient levels; steroid hormone receptor signaling pathway; response to drug; transcription, DNA-dependent; male gonad development; vagina development; Sertoli cell proliferation; response to testosterone stimulus; Sertoli cell development; regulation of cell proliferation; response to genistein; response to ethanol; response to estrogen stimulus; positive regulation of transcription factor activity; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; brain development; response to activity; negative regulation of behavior; response to water deprivation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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