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anti-14-3-3 alpha/beta antibody :: Rabbit 14-3-3 alpha/beta Polyclonal Antibody

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Catalog # MBS5300303
Unit / Price
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  0.1 mg  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

14-3-3 alpha/beta, Polyclonal Antibody

Full Product Name

14-3-3 alpha/beta antibody (FITC)

Product Synonym Names
Polyclonal 14-3-3 alpha/beta; Anti-14-3-3 alpha/beta; Protein 1054; 14-3-3 alpha; 14-3-3 beta; 14-3-3 alpha + beta; 14-3-3 beta/alpha; 14.3.3 alpha/beta; 14.3.3 alpha; 14.3.3 beta; Protein kinase C inhibitor protein 1; KCIP 1; 14 3 3 alpha/beta N terminally processed
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601289
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
14-3-3 alpha/beta antibody (FITC) was purified by Ammonium Sulfate precipitation
Form/Format
Supplied with 0.03% Proclin 300, 50% Glycerol and 0.01M PBS, PH 7.4
Biological Significance
14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival.
Tag/Conjugate
FITC
Immunogen
14-3-3 alpha/beta antibody (FITC) was raised in Rabbit using recombinant human 14-3-3 alpha/beta protein as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage and -20 degree C for long term storage. Avoid repeat freeze/thaw cycles
Other Notes
Small volumes of anti-14-3-3 alpha/beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-14-3-3 alpha/beta antibody
Rabbit polyclonal 14-3-3 alpha/beta antibody (FITC)
Applications Tested/Suitable for anti-14-3-3 alpha/beta antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Western Blot (WB) of anti-14-3-3 alpha/beta antibody

anti-14-3-3 alpha/beta antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for 14-3-3 alpha/beta. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,850 Da
NCBI Official Full Name
14-3-3 protein beta/alpha
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
NCBI Official Symbol
YWHAB  [Similar Products]
NCBI Official Synonym Symbols
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
  [Similar Products]
NCBI Protein Information
14-3-3 protein beta/alpha
UniProt Protein Name
14-3-3 protein beta/alpha
UniProt Synonym Protein Names
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
UniProt Gene Name
YWHAB  [Similar Products]
UniProt Synonym Gene Names
KCIP-1  [Similar Products]
UniProt Entry Name
1433B_HUMAN
NCBI Summary for 14-3-3 alpha/beta
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for 14-3-3 alpha/beta
14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; transcriptional repressor complex; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; protein complex binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding

Biological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of catalytic activity; epidermal growth factor receptor signaling pathway; axon guidance; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; apoptosis; protein heterooligomerization; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; cytoplasmic sequestering of protein; insulin receptor signaling pathway; innate immune response; gene expression; negative regulation of transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway; protein targeting
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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