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anti-ABAT antibody :: Rabbit 4-aminobutyrate aminotransferase Polyclonal Antibody

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Catalog # MBS1492760
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

4-aminobutyrate aminotransferase (ABAT), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human 4-aminobutyrate aminotransferase, mitochondrial polyclonal Antibody(ABAT)

Product Synonym Names
(S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; ABAT; GABAT
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
137150
3D Structure
ModBase 3D Structure for P80404
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human 4-aminobutyrate aminotransferase, mitochondrial protein(29-300aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160120
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ABAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABAT antibody
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Applications Tested/Suitable for anti-ABAT antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ABAT antibody
Recommended dilution: WB:1:500-5000
IHC:1:20-1:200

Western Blot (WB) of anti-ABAT antibody
All lanes: 4-aminobutyrate aminotransferase, mitochondrial antibody at 10ug/ml
Lane 1:rat liver tissue
Lane 2:mouse pancreas tissue
Lane 3:mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 56kDa
Observed band size: 56kDa

anti-ABAT antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABAT antibody
Immunohistochemistry of paraffin-embedded human liver using MBS1492760 at dilution 1:100
anti-ABAT antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ABAT antibody
Immunohistochemistry of paraffin-embedded human placenta using MBS1492760 at dilution 1:100
anti-ABAT antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ABAT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,439 Da
NCBI Official Full Name
4-aminobutyrate aminotransferase, mitochondrial
NCBI Official Synonym Full Names
4-aminobutyrate aminotransferase
NCBI Official Symbol
NCBI Official Synonym Symbols
GABAT; NPD009; GABA-AT
  [Similar Products]
NCBI Protein Information
4-aminobutyrate aminotransferase, mitochondrial
UniProt Protein Name
4-aminobutyrate aminotransferase, mitochondrial
UniProt Synonym Protein Names
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22); GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT
UniProt Gene Name
UniProt Synonym Gene Names
GABAT; GABA-AT; GABA transaminase; GABA-T  [Similar Products]
UniProt Entry Name
GABT_HUMAN
NCBI Summary for ABAT
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABAT
ABAT: Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Defects in ABAT are a cause of GABA transaminase deficiency (GABATD). The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; Other Amino Acids Metabolism - beta-alanine; EC 2.6.1.22; EC 2.6.1.19; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Transferase

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: 4-aminobutyrate transaminase complex; mitochondrial matrix; mitochondrion; neuron projection

Molecular Function: (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; iron-sulfur cluster binding; metal ion binding; protein homodimerization activity; pyridoxal phosphate binding; succinate-semialdehyde dehydrogenase binding

Biological Process: aging; behavioral response to cocaine; cerebellum development; copulation; gamma-aminobutyric acid biosynthetic process; gamma-aminobutyric acid catabolic process; locomotory behavior; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of gamma-aminobutyric acid secretion; neurotransmitter catabolic process; neurotransmitter secretion; positive regulation of dopamine metabolic process; positive regulation of heat generation; positive regulation of insulin secretion; response to drug; response to ethanol; response to hypoxia; response to iron ion; response to nicotine; synaptic transmission

Disease: Gaba-transaminase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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