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anti-AAAS antibody :: Rabbit AAAS Polyclonal Antibody

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Catalog # MBS2519166
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

AAAS, Polyclonal Antibody

Also Known As

AAAS Polyclonal Antibody

Product Synonym Names
AAA; AAASb; GL003; ALADIN; ADRACALA; ADRACALIN
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
513
OMIM
231550
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Immunogen
Recombinant protein of human AAAS
Calculated Molecular Weight: 60kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-AAAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AAAS antibody
The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-AAAS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AAAS antibody
WB: 1:200-1:1000
IHC: 1:50-1:200

Western Blot (WB) of anti-AAAS antibody
Western Blot analysis of 293T, hela and PC3 cell using AAAS Polyclonal Antibody at dilution of 1:400
anti-AAAS antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AAAS antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer using AAAS Polyclonal Antibody at dilution of 1:20
anti-AAAS antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-AAAS antibody
Immunohistochemistry of paraffin-embedded Human brain using AAAS Polyclonal Antibody at dilution of 1:20
anti-AAAS antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AAAS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,814 Da
NCBI Official Full Name
aladin isoform 2
NCBI Official Synonym Full Names
achalasia, adrenocortical insufficiency, alacrimia
NCBI Official Symbol
NCBI Official Synonym Symbols
AAA; AAASb; GL003; ALADIN; ADRACALA; ADRACALIN
  [Similar Products]
NCBI Protein Information
aladin; Allgrove, triple-A
UniProt Protein Name
Aladin
UniProt Synonym Protein Names
Adracalin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ADRACALA  [Similar Products]
UniProt Entry Name
AAAS_HUMAN
NCBI Summary for AAAS
The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for AAAS
AAAS: Plays a role in the normal development of the peripheral and central nervous system. Defects in AAAS are the cause of achalasia-addisonianism- alacrima syndrome (AAAS); also known as triple-A syndrome or Allgrove syndrome. AAAS is an autosomal recessive disorder characterized by adreno-corticotropic hormone (ACTH)- resistant adrenal failure, achalasia of the esophageal cardia and alacrima. The syndrome is associated with variable and progressive neurological impairment involving the central, peripheral, and autonomic nervous system. Other features such as palmoplantar hyperkeratosis, short stature, facial dysmorphy and osteoporosis may also be present. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Nuclear envelope

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; centrosome; nuclear membrane; membrane; cytoplasm; nuclear pore; nuclear envelope; nucleus

Biological Process: mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; nucleocytoplasmic transport; viral infectious cycle; learning; glucose transport; protein transport; fertilization; regulation of nucleocytoplasmic transport; hexose transport; carbohydrate metabolic process; viral transcription; gene expression; mitotic cell cycle; transmembrane transport

Disease: Achalasia-addisonianism-alacrima Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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