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anti-AANAT antibody :: Rabbit AANAT Polyclonal Antibody

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Catalog # MBS2517280
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

AANAT, Polyclonal Antibody

Popular Item
Full Product Name

AANAT Polyclonal Antibody

Product Synonym Names
DSPS; SNAT
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600950
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.3mg/mL (lot specific)
Immunogen
Recombinant protein of human AANAT
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-AANAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AANAT antibody
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-AANAT antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AANAT antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-AANAT antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using AANAT Polyclonal Antibody at dilution 1:40
anti-AANAT antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-AANAT antibody
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using AANAT Polyclonal Antibody at dilution 1:40
anti-AANAT antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AANAT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,432 Da
NCBI Official Full Name
AANAT protein
NCBI Official Synonym Full Names
aralkylamine N-acetyltransferase
NCBI Official Symbol
AANAT  [Similar Products]
NCBI Official Synonym Symbols
DSPS; SNAT
  [Similar Products]
NCBI Protein Information
serotonin N-acetyltransferase; arylalkylamine N-acetyltransferase; serotonin acetylase
UniProt Protein Name
Serotonin N-acetyltransferase
UniProt Synonym Protein Names
Aralkylamine N-acetyltransferase; AA-NAT
UniProt Gene Name
AANAT  [Similar Products]
UniProt Synonym Gene Names
SNAT; Serotonin acetylase; AA-NAT  [Similar Products]
UniProt Entry Name
SNAT_HUMAN
NCBI Summary for AANAT
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for AANAT
AA-NAT var1: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect.

Protein type: Amino Acid Metabolism - tryptophan; EC 2.3.1.87; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: perinuclear region of cytoplasm; cytosol

Molecular Function: arylamine N-acetyltransferase activity; aralkylamine N-acetyltransferase activity

Biological Process: N-terminal protein amino acid acetylation; circadian rhythm; response to light stimulus; melatonin biosynthetic process; response to copper ion; indolalkylamine biosynthetic process; response to zinc ion; response to cytokine stimulus; response to calcium ion; response to corticosterone stimulus; response to insulin stimulus

Disease: Delayed Sleep Phase Syndrome, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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