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anti-ABCA2 antibody :: Goat ABCA2 Polyclonal Antibody

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Catalog # MBS422085
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
anti-ABCA2 antibody
Product Name

ABCA2, Polyclonal Antibody

Also Known As

Goat anti-ABCA2 Antibody

Product Synonym Names
ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2; ABC2; MGC129761; ATP-binding cassette, sub-family A, member 2; OTTHUMP00000064733; ABCA2 antibody; ATP-binding cassette; sub-family A (ABC1); member 2 antibody; ABC2 antibody; MGC129761 antibody; ATP-binding cassette; sub-family A; member 2 antibody; OTTHUMP00000064733 antibody
Antibody/Peptide Pairs
ABCA2 peptide (MBS425936) is used for blocking the activity of ABCA2 antibody (MBS422085)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2436
Immunogen Sequence
KKQSDNLEQQ ETEP
OMIM
600047
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-KKQSDNLEQQETEP, from the internal region of the protein sequence according to NP_001597.2; NP_997698.1.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_001597.2; NP_997698.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCA2 antibody
Peptide ELISA (EIA)
Application Notes for anti-ABCA2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments gave an approx 35kDa band in Human Brain (Amygdala, Frontal Cortex, Hippocampus and Substantia Nigra) lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 270kDa according to NP_001597.2 and of 273kDa according to. NP_997698.1. The 35kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ABCA2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_997698.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
269,988 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 2 isoform a
NCBI Official Synonym Full Names
ATP binding cassette subfamily A member 2
NCBI Official Symbol
ABCA2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
ATP-binding cassette sub-family A member 2
UniProt Protein Name
ATP-binding cassette sub-family A member 2
UniProt Synonym Protein Names
ATP-binding cassette transporter 2; ATP-binding cassette 2
Protein Family
UniProt Gene Name
ABCA2  [Similar Products]
UniProt Synonym Gene Names
ABC2; KIAA1062; ATP-binding cassette 2  [Similar Products]
UniProt Entry Name
ABCA2_HUMAN
NCBI Summary for ABCA2
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA2
ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: ATP-binding cassette (ABC) transporter complex; cytoplasmic membrane-bound vesicle; endosome; endosome membrane; integral to membrane; lysosomal membrane; lysosome; membrane; microtubule organizing center

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding

Biological Process: cholesterol efflux; cholesterol homeostasis; lipid metabolic process; phospholipid efflux; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus; transmembrane transport; transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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