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anti-ABCD3 antibody :: Goat ABCD3 Polyclonal Antibody

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Catalog # MBS421942
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Product Name

ABCD3, Polyclonal Antibody

Also Known As

Goat anti-ABCD3 Antibody

Product Synonym Names
ABCD3; ATP-binding cassette, sub-family D (ALD), member 3; ABC43; PMP70; PXMP1; ATP-binding cassette, sub-family D, member 3; Peroxisomal membrane protein-1 (70kD); dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); peroxisoma; ABCD3 antibody; ATP-binding cassette; sub-family D (ALD); member 3 antibody; ABC43 antibody; PMP70 antibody; PXMP1 antibody; ATP-binding cassette; sub-family D; member 3 antibody; Peroxisomal membrane protein-1 (70kD) antibody; dJ824O18.1 (ATP-binding cassette; sub-family D (ALD); member 3 (PMP70; PXMP1)) antibody; peroxisomal membrane protein 1 (70kD; Zellweger syndrome) antibody; ABCD3
Matching Pairs
Unconjugated Antibody: ABCD3 (MBS421942)
Biotin Conjugated Antibody: ABCD3 (MBS423686)
Antibody/Peptide Pairs
ABCD3 peptide (MBS425530) is used for blocking the activity of ABCD3 antibody (MBS421942)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
659
Immunogen Sequence
PDGREDQKRK GISD
OMIM
170995
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PDGREDQKRKGISD, from the internal region of the protein sequence according to NP_002849.1.
Epitope
Internal region
Note
This antibody is expected to recognize one isoform (NP_002849.1) only.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCD3 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ABCD3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Testis shows vesicular staining in Sertoli cells. Recommended concentration, 2.5-3.8ug/ml.
Western Blot: Approx.70kDa band observed in Human Kidney lysates (calculated MW of 75.5kDa according to NP_002849.1). Recommended concentration: 0.2-0.6 ug/ml.

Western Blot (WB) of anti-ABCD3 antibody
(0.2ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ABCD3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABCD3 antibody
(3.8ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-ABCD3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ABCD3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,121 Da
NCBI Official Full Name
ATP-binding cassette sub-family D member 3 isoform a
NCBI Official Synonym Full Names
ATP binding cassette subfamily D member 3
NCBI Official Symbol
ABCD3  [Similar Products]
NCBI Official Synonym Symbols
ZWS2; ABC43; CBAS5; PMP70; PXMP1
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 3
UniProt Protein Name
ATP-binding cassette sub-family D member 3
UniProt Synonym Protein Names
70 kDa peroxisomal membrane protein; PMP70
Protein Family
UniProt Gene Name
ABCD3  [Similar Products]
UniProt Synonym Gene Names
PMP70; PXMP1; PMP70  [Similar Products]
UniProt Entry Name
ABCD3_HUMAN
NCBI Summary for ABCD3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD3
ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes.

Protein type: Membrane protein, multi-pass; Transporter, ABC family; Transporter; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p21.3

Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; membrane; mitochondrial inner membrane; peroxisomal matrix; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity; protein self-association

Biological Process: fatty acid beta-oxidation; fatty acid biosynthetic process; peroxisomal long-chain fatty acid import; peroxisome organization and biogenesis; response to drug; response to organic cyclic substance; transmembrane transport; very-long-chain fatty acid catabolic process

Disease: Bile Acid Synthesis Defect, Congenital, 5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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