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anti-ABHD12 antibody :: Goat ABHD12 Polyclonal Antibody

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Catalog # MBS421831
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABHD12, Polyclonal Antibody

Also Known As

Goat anti-ABHD12 Antibody

Product Synonym Names
ABHD12; abhydrolase domain containing 12; ABHD12A; BEM46L2; C20orf22; DKFZP434P106; dJ965G21.2; ABHD12 antibody; abhydrolase domain containing 12 antibody; ABHD12A antibody; BEM46L2 antibody; C20orf22 antibody; DKFZP434P106 antibody; dJ965G21.2 antibody; ABHD12
Antibody/Peptide Pairs
ABHD12 peptide (MBS426264) is used for blocking the activity of ABHD12 antibody (MBS421831)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Immunogen Sequence
Species Reactivity
Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul (lot specific)
Peptide with sequence C-REFLGKSEPEHQH, from the C Terminus of the protein sequence according to NP_001035937.1; NP_056415.1.
C Terminus
This antibody is expected to recognize isoform a (NP_001035937.1) only.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABHD12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABHD12 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ABHD12 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: approx. 40kDa band observed in Mouse Brain and Rat Brain lysates (calculated MW of 45.1kDa according to Human NP_001035937.1 and of 45.3kDa according to Mouse NP_077785.2). Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-ABHD12 antibody
(0.3 ug/ ml) staining of Mouse Brain lysate (35 ug/ protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ABHD12 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABHD12. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_056415.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,387 Da
NCBI Official Full Name
monoacylglycerol lipase ABHD12 isoform a
NCBI Official Synonym Full Names
abhydrolase domain containing 12
NCBI Official Symbol
ABHD12  [Similar Products]
NCBI Official Synonym Symbols
PHARC; ABHD12A; BEM46L2; C20orf22; dJ965G21.2
  [Similar Products]
NCBI Protein Information
monoacylglycerol lipase ABHD12
UniProt Protein Name
Monoacylglycerol lipase ABHD12
UniProt Synonym Protein Names
2-arachidonoylglycerol hydrolaseCurated; Abhydrolase domain-containing protein 12Curated
Protein Family
UniProt Gene Name
ABHD12  [Similar Products]
UniProt Entry Name
NCBI Summary for ABHD12
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
UniProt Comments for ABHD12
ABHD12: Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses. Belongs to the serine esterase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: acylglycerol lipase activity

Biological Process: acylglycerol catabolic process; adult walking behavior; phosphatidylserine catabolic process

Disease: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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