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anti-ACADL antibody :: Rabbit ACADL Polyclonal Antibody

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Catalog # MBS9204274
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ACADL, Polyclonal Antibody

Also Known As

ACADL Antibody (N-term)

Product Synonym Names
Long-chain specific acyl-CoA dehydrogenase; mitochondrial; LCAD; ACADL
Antibody/Peptide Pairs
ACADL peptide (MBS9219686) is used for blocking the activity of ACADL antibody (MBS9204274)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
14-43
Immunogen Sequence Length
430
OMIM
201475
3D Structure
ModBase 3D Structure for P28330
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse, rat
Specificity
This ACADL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ACADL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Crown Antibody
Yes
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ACADL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACADL antibody
The protein encoded by this gene belongs to the acyl-CoA
dehydrogenase family, which is a family of mitochondrial
flavoenzymes involved in fatty acid and branched chain amino-acid
metabolism. This protein is one of the four enzymes that catalyze
the initial step of mitochondrial beta-oxidation of straight-chain
fatty acid. Defects in this gene are the cause of long-chain
acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic
hypoglycemia.
Applications Tested/Suitable for anti-ACADL antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ACADL antibody
WB~~1:1000

Western Blot (WB) of anti-ACADL antibody
Western blot analysis of lysates from HepG2 cell line and mouse kidney, rat spleen tissue lysates(from left to right), using ACADL Antibody (N-term). MBS9204274 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
anti-ACADL antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACADL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47656
NCBI Official Full Name
long-chain specific acyl-CoA dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, long chain
NCBI Official Symbol
ACADL  [Similar Products]
NCBI Official Synonym Symbols
LCAD; ACAD4
  [Similar Products]
NCBI Protein Information
long-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Gene Name
ACADL  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ACADL_HUMAN
NCBI Summary for ACADL
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ACADL
ACADL: Defects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD). An inborn error of mitochondrial fatty acid beta-oxidation which leads to impaired long-chain fatty acid beta-oxidation. It is clinically heterogeneous, with three major phenotypes: a severe childhood form characterized by early onset, high mortality and high incidence of cardiomyopathy; a milder childhood form with later onset, characterized by hypoketotic hypoglycemia, low mortality and rare cardiomyopathy; an adult form, with isolated skeletal muscle involvement, rhabdomyolysis and myoglobinuria, usually triggered by exercise or fasting. Belongs to the acyl-CoA dehydrogenase family.

Protein type: Mitochondrial; Oxidoreductase; Lipid Metabolism - fatty acid; EC 1.3.8.8

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial membrane

Molecular Function: palmitoyl-CoA oxidase activity; acyl-CoA dehydrogenase activity; FAD binding; acyl-CoA binding; long-chain-acyl-CoA dehydrogenase activity

Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; cellular lipid catabolic process; carnitine catabolic process; thermoregulation; cellular lipid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; negative regulation of fatty acid oxidation; negative regulation of fatty acid biosynthetic process; protein homotetramerization; long-chain fatty acid catabolic process
Product References and Citations for anti-ACADL antibody
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Maher, A.C., et al. Mol. Genet. Metab. 100(2):163-167(2010)
Illig, T., et al. Nat. Genet. 42(2):137-141(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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