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anti-ACADS antibody :: Rabbit ACADS Polyclonal Antibody

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Catalog # MBS125363
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Product Name

ACADS, Polyclonal Antibody

Popular Item
Full Product Name

ACADS Polyclonal Antibody

Product Synonym Names
ACAD3; SCAD
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 606885
3D Structure
ModBase 3D Structure for P16219
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Species
Human
Immunogen
Recombinant Protein
Immunogen
Fusion protein of human ACADS
Calculated Molecular Weight
44kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-ACADS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACADS antibody
This gene encodes a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency. [provided by RefSeq, Jul 2008]
Product Categories/Family for anti-ACADS antibody
Applications Tested/Suitable for anti-ACADS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACADS antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100

Western Blot (WB) of anti-ACADS antibody
Western blot analysis of extracts of various cell lines, using ACADS antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 15s.
anti-ACADS antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ACADS antibody
Immunohistochemistry of paraffin-embedded human liver cancer using ACADS antibody at dilution of 1:100 (40x lens).
anti-ACADS antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ACADS antibody
Immunohistochemistry of paraffin-embedded human liver injury using ACADS antibody at dilution of 1:100 (40x lens).
anti-ACADS antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ACADS antibody
Immunofluorescence analysis of U2OS cells using ACADS antibody. Blue: DAPI for nuclear staining.
anti-ACADS antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ACADS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
412
NCBI Official Full Name
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, C-2 to C-3 short chain
NCBI Official Symbol
ACADS  [Similar Products]
NCBI Official Synonym Symbols
SCAD; ACAD3
  [Similar Products]
NCBI Protein Information
short-chain specific acyl-CoA dehydrogenase, mitochondrial; butyryl-CoA dehydrogenase; unsaturated acyl-CoA reductase; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; mitochondrial short-chain specific acyl-CoA dehydrogenase
UniProt Protein Name
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Butyryl-CoA dehydrogenase
UniProt Gene Name
ACADS  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ACADS_HUMAN
NCBI Summary for ACADS
This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
UniProt Comments for ACADS
ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in adults. Belongs to the acyl-CoA dehydrogenase family.

Protein type: Lipid Metabolism - fatty acid; Mitochondrial; Carbohydrate Metabolism - butanoate; Oxidoreductase; EC 1.3.8.1; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; nucleus

Molecular Function: acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; FAD binding; acyl-CoA binding

Biological Process: response to starvation; fatty acid beta-oxidation; response to glucocorticoid stimulus; cellular lipid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; butyrate catabolic process; protein homotetramerization

Disease: Acyl-coa Dehydrogenase, Short-chain, Deficiency Of
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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