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anti-ACIN1 antibody :: Rabbit Acinus Polyclonal Antibody

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Catalog # MBS8303973
Unit / Price
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  0.03 mL  /  $165 +1 FREE 8GB USB
  0.1 mL  /  $245 +1 FREE 8GB USB
  0.2 mL  /  $350 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Acinus (ACIN1), Polyclonal Antibody

Full Product Name

Anti-Acinus (pS1180) Antibody

Product Synonym Names
ACIN1; ACINUS; KIAA0670; Apoptotic chromatin condensation inducer in the nucleus; Acinus; SCAF4; KIAA1172; SFRS15; Splicing factor arginine/serine-rich 15; CTD-binding SR-like protein RA4; SR-related and CTD-associated factor 4; PNISR; C6orf111; SFRS18; SRRP130; HSPC261; HSPC306; Arginine/serine-rich protein PNISR; PNN-interacting serine/arginine-rich protein; SR-related protein; SR-rich protein; Serine/arginine-rich-splicing regulatory protein 130; SRrp130; Splicing factor arginine/serine-rich 130; Splicing factor arginine/serine-rich 18; RBM39; HCC1; RNPC2; RNA-binding protein 39; Hepatocellular carcinoma protein 1; RNA-binding motif protein 39; RNA-binding region-containing protein 2; Splicing factor HCC1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UKV3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Acinus (pS1180) protein.
Purity/Purification
Purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Acinus.
Preparation and Storage
Upon delivery aliquot and store at-20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ACIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACIN1 antibody
Rabbit polyclonal antibody to Acinus (pS1180)
Applications Tested/Suitable for anti-ACIN1 antibody
Western Blot (WB)
Application Notes for anti-ACIN1 antibody
WB: 1:500-1:1000

Western Blot (WB) of anti-ACIN1 antibody
Western blot analysis of Acinus (pS1180) expression in A549 (A), Hela (B), Jurkat (C), NIH3T3 (D), H9C2 (E), PC12 (F) whole cell lysates.
anti-ACIN1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACIN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,948 Da
NCBI Official Full Name
apoptotic chromatin condensation inducer in the nucleus isoform 2
NCBI Official Synonym Full Names
apoptotic chromatin condensation inducer 1
NCBI Official Symbol
ACIN1  [Similar Products]
NCBI Official Synonym Symbols
ACN; ACINUS; fSAP152
  [Similar Products]
NCBI Protein Information
apoptotic chromatin condensation inducer in the nucleus
UniProt Protein Name
Apoptotic chromatin condensation inducer in the nucleus
UniProt Gene Name
ACIN1  [Similar Products]
UniProt Synonym Gene Names
ACINUS; KIAA0670; Acinus  [Similar Products]
NCBI Summary for ACIN1
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for ACIN1
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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