NP_004448.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 70 kDa Predicted: 81 kDa
NCBI Official Full Name
long-chain-fatty-acid--CoA ligase 3
NCBI Official Synonym Full Names
acyl-CoA synthetase long chain family member 3
NCBI Official Synonym Symbols
ACS3; FACL3; LACS3; LACS 3; PRO2194 [Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 3
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 3
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 3; LACS 3
UniProt Synonym Gene Names
NCBI Summary for ACSL3
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACSL3
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
Research Articles on ACSL3
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Products associated with anti-ACSL3 antibody
Pathways associated with anti-ACSL3 antibody
Diseases associated with anti-ACSL3 antibody
Organs/Tissues associated with anti-ACSL3 antibody
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