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anti-ACSL6 antibody :: Rabbit ACSL6 Polyclonal Antibody

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Catalog # MBS9128844
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ACSL6, Polyclonal Antibody

Popular Item
Also Known As

ACSL6 Polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
722
OMIM
604443
3D Structure
ModBase 3D Structure for Q9UKU0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 383-622 of human ACSL6 (NP_001192180.1)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW
69 kDa/ 74 kDa / 76 kDa/ 77 kDa/ 79 kDa/ 80 kDa
Observed MW
78kDa
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-ACSL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACSL6 antibody
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-ACSL6 antibody
Western Blot
Application Notes for anti-ACSL6 antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:200

Western Blot (WB) of anti-ACSL6 antibody
Western blot analysis of extracts of various cell lines, using ACSL6 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-ACSL6 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACSL6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
long-chain-fatty-acid--CoA ligase 6 isoform b
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 6
NCBI Official Symbol
ACSL6  [Similar Products]
NCBI Official Synonym Symbols
ACS2; FACL6; LACS2; LACS5; LACS 6
  [Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 6
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 6
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 6; LACS 6
UniProt Gene Name
ACSL6  [Similar Products]
UniProt Synonym Gene Names
ACS2; FACL6; KIAA0837; LACS5; LACS 6  [Similar Products]
UniProt Entry Name
ACSL6_HUMAN
NCBI Summary for ACSL6
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
UniProt Comments for ACSL6
ACSL6: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6. Belongs to the ATP-dependent AMP-binding enzyme family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Membrane protein, integral; Lipid Metabolism - fatty acid; EC 6.2.1.3

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; plasma membrane; integral to membrane; nucleus

Molecular Function: enzyme binding; protein homodimerization activity; ATP binding; long-chain-fatty-acid-CoA ligase activity

Biological Process: response to gravity; acyl-CoA metabolic process; cellular response to insulin stimulus; response to steroid hormone stimulus; neuroblast proliferation; response to hypoxia; neuron development; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid transport; response to nutrient; phospholipid biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-ACSL6 antibody
 Reference Product  PubMed Publications
 PHYH antibody  >1 publications with ACSL6 and PHYH
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