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anti-ACVR1 antibody :: Rabbit ACVR1C Polyclonal Antibody

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Catalog # MBS151152
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ACVR1C, Polyclonal Antibody

Also Known As

ACVR1C Antibody

Product Synonym Names
ACVR1C; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; Activin receptor type-1; Activin receptor type I; ACTR-I; activin A receptor, type I
Antibody/Peptide Pairs
ACVR1C peptide (MBS152334) is used for blocking the activity of ACVR1C antibody (MBS151152)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
509
OMIM
gene 135100
3D Structure
ModBase 3D Structure for Q04771
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.
Purity/Purification
ACVR1C Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ACVR1C antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ACVR1C.
Buffer
ACVR1C Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ACVR1C antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-ACVR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACVR1 antibody
ACVR1C Antibody: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.
Applications Tested/Suitable for anti-ACVR1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-ACVR1 antibody
ACVR1C antibody can be used for detection of ACVR1C by Western blot at 1 and 2 mug/mL.

Western Blot (WB) of anti-ACVR1 antibody
Western blot analysis of ACVR1C in human placenta tissue lysate with ACVR1C antibody at (A) 1 and (B) 2 μg/mL.
anti-ACVR1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACVR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
57,153 Da
NCBI Official Full Name
activin receptor type-1
NCBI Official Synonym Full Names
activin A receptor, type I
NCBI Official Symbol
ACVR1  [Similar Products]
NCBI Official Synonym Symbols
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
  [Similar Products]
NCBI Protein Information
activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1
UniProt Protein Name
Activin receptor type-1
UniProt Synonym Protein Names
Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
Protein Family
UniProt Gene Name
ACVR1  [Similar Products]
UniProt Synonym Gene Names
ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I  [Similar Products]
UniProt Entry Name
ACVR1_HUMAN
NCBI Summary for ACVR1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
UniProt Comments for ACVR1
ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: apical part of cell; integral to plasma membrane; activin receptor complex

Molecular Function: protein homodimerization activity; metal ion binding; peptide hormone binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; mesoderm formation; regulation of skeletal muscle development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of ossification; determination of left/right symmetry; urogenital system development; acute inflammatory response; G1/S transition of mitotic cell cycle

Disease: Fibrodysplasia Ossificans Progressiva
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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