AAH41692.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Acyl-CoA synthetase long-chain family member 3
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 3
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 3; LACS 3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; fatty-acid-Coenzyme A ligase, long-chain 3
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 3
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 3; LACS 3
UniProt Synonym Gene Names
UniProt Entry Name
ACSL3_HUMAN
NCBI Summary for ACSL3
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACSL3
ACSL3: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Membrane protein, integral; EC 6.2.1.3; Lipid Metabolism - fatty acid; Ligase
Chromosomal Location of Human Ortholog: 2q34-q35
Cellular Component: Golgi apparatus; peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane; lipid particle
Molecular Function: protein domain specific binding; protein kinase binding; ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: positive regulation of Golgi to plasma membrane protein transport; positive regulation of secretion; long-chain fatty acid metabolic process; brain development; response to organic cyclic substance; response to nutrient; fatty acid biosynthetic process
Research Articles on ACSL3
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Products associated with anti-ACSL3 antibody
Pathways associated with anti-ACSL3 antibody
Diseases associated with anti-ACSL3 antibody
Organs/Tissues associated with anti-ACSL3 antibody
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