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anti-ADORA2B antibody :: Rabbit Adenosine A2b Receptor Polyclonal Antibody

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Catalog # MBS610342
Unit / Price
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  0.1 mg  /  $745 +1 FREE 8GB USB
anti-ADORA2B antibody
Product Name

Adenosine A2b Receptor (ADORA2B), Polyclonal Antibody

Full Product Name

Adenosine A2b Receptor (A2b)

Product Synonym Names
Anti -Adenosine A2b Receptor (A2b)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (15848231..15879210). Location: 17p12
OMIM
600446
3D Structure
ModBase 3D Structure for P29275
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes Adenosine A2b Receptor. Species crossreactivity: mouse and rat.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.5, 0.1% BSA.
Immunogen
A 16 aa sequence corresponding to human brain A2bR gene (1). This region corresponds to the 2nd extracellular domain. A cysteine has been added at the NH2 terminus (KLH). Species sequence homology: 75% 12/16 AA) rat, 62% (11/16 AA) mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ADORA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADORA2B antibody
The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis. Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon, biochemical and pharmacological criteria, ARs have been classified into A1, A2a, A2b, and A3. The high affinity receptor A1 inhibits adenyl cyclase, whereas low affinity receptor A2a stimulates the cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in coronary artery. Various, ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and predicted to contain 7 transmembrane domains. The N-termini are predicted to be extracellular and the C-termini cytoplasmic. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromos.1).
Product Categories/Family for anti-ADORA2B antibody
Applications Tested/Suitable for anti-ADORA2B antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ADORA2B antibody
Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence.
Dilution: Western Blot: 1-10ug/ml using ECL.
ELISA: 1:10,000-50,000 using 50-100ng A1R control peptide/well.
Immunohistochemistry (frozen): 10-50ug/ml.
Immunofluorescence: 10-50ug/ml.
NCBI/Uniprot data below describe general gene information for ADORA2B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
36,333 Da[Similar Products]
NCBI Official Full Name
adenosine A2b receptor
NCBI Official Synonym Full Names
adenosine A2b receptor
NCBI Official Symbol
ADORA2B  [Similar Products]
NCBI Official Synonym Symbols
ADORA2
  [Similar Products]
NCBI Protein Information
adenosine receptor A2b; OTTHUMP00000065212
UniProt Protein Name
Adenosine receptor A2b
Protein Family
UniProt Gene Name
ADORA2B  [Similar Products]
UniProt Entry Name
AA2BR_HUMAN
NCBI Summary for ADORA2B
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]
UniProt Comments for ADORA2B
ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: relaxation of vascular smooth muscle; activation of MAPK activity; adenylate cyclase activation; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of guanylate cyclase activity; excretion; G-protein signaling, adenylate cyclase activating pathway; positive regulation of chemokine production; G-protein coupled receptor protein signaling pathway; positive regulation of chronic inflammatory response to non-antigenic stimulus; cellular response to extracellular stimulus; JNK cascade; cellular defense response; adenosine receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-ADORA2B antibody
 Reference Product  PubMed Publications
 ADA antibody  >1 publications with ADORA2B and ADA
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