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anti-ADORA2B antibody :: Rabbit ADORA2B Polyclonal Antibody

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Catalog # MBS153447
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ADORA2B, Polyclonal Antibody

Popular Item
Also Known As

ADORA2B Antibody

Product Synonym Names
Adenosine receptor A2b; ADORA2; adenosine A2b receptor
Antibody/Peptide Pairs
ADORA2B peptide (MBS153991) is used for blocking the activity of ADORA2B antibody (MBS153447)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
332
OMIM
600446
3D Structure
ModBase 3D Structure for P29275
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.
Purity/Purification
ADORA2B antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ADORA2B antibody was raised against a 19 amino acid peptide near the amino terminus of human ADORA2B.
Buffer
ADORA2B antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ADORA2B antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Other Notes
Small volumes of anti-ADORA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADORA2B antibody
The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2). Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5). Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6).
Applications Tested/Suitable for anti-ADORA2B antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ADORA2B antibody
ADORA2B antibody can be used for detection of ADORA2B by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ADORA2B antibody
Western blot analysis of ADORA2B in mouse colon tissue lysate with ADORA2B antibody at (A) 0.5 and (B) 1 μg/ml.
anti-ADORA2B antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-ADORA2B antibody
Immunofluorescence of ADORA2B in rat colon tissue with ADORA2B antibody at 20 μg/mL.
anti-ADORA2B antibody Immunofluorescence (IF) image
Immunohistochemistry (IHC) of anti-ADORA2B antibody
Immunohistochemistry of ADORA2B in rat colon tissue with ADORA2B antibody at 5 μg/mL.
anti-ADORA2B antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ADORA2B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 37 kDa

Observed: 41 kDa
NCBI Official Full Name
adenosine receptor A2b
NCBI Official Synonym Full Names
adenosine A2b receptor
NCBI Official Symbol
ADORA2B  [Similar Products]
NCBI Official Synonym Symbols
ADORA2
  [Similar Products]
NCBI Protein Information
adenosine receptor A2b
UniProt Protein Name
Adenosine receptor A2b
Protein Family
UniProt Gene Name
ADORA2B  [Similar Products]
UniProt Entry Name
AA2BR_HUMAN
NCBI Summary for ADORA2B
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
UniProt Comments for ADORA2B
ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: relaxation of vascular smooth muscle; activation of MAPK activity; adenylate cyclase activation; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of guanylate cyclase activity; excretion; G-protein signaling, adenylate cyclase activating pathway; positive regulation of chemokine production; G-protein coupled receptor protein signaling pathway; positive regulation of chronic inflammatory response to non-antigenic stimulus; cellular response to extracellular stimulus; cellular defense response; JNK cascade; adenosine receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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