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anti-ADRA1A antibody :: Rabbit ADRA1A Polyclonal Antibody

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Catalog # MBS126515 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ADRA1A, Polyclonal Antibody

Full Product Name

ADRA1A Polyclonal Antibody

Product Synonym Names
ADRA1C; ADRA1L1; ALPHA1AAR
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
104221
3D Structure
ModBase 3D Structure for P35348
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Species
Human
Route
Synthetic Peptide
Immunogen
A synthetic peptide of human ADRA1A
Calculated Molecular Weight
52kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-ADRA1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADRA1A antibody
ADRA1A, also named as ADRA1C, belongs to the G-protein coupled receptor 1 family. ADRA1A mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. The antibody is specific to ADRA1A.
Product Categories/Family for anti-ADRA1A antibody
Applications Tested/Suitable for anti-ADRA1A antibody
Western Blot (WB)
Application Notes for anti-ADRA1A antibody
WB: 1:500 - 1:2000

Western Blot (WB) of anti-ADRA1A antibody
Western blot analysis of extracts of various cell lines, using ADRA1A antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-ADRA1A antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ADRA1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
466
NCBI Official Full Name
Alpha-1A adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 1A
NCBI Official Symbol
ADRA1A  [Similar Products]
NCBI Official Synonym Symbols
ADRA1C; ADRA1L1; ALPHA1AAR
  [Similar Products]
NCBI Protein Information
alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; G protein coupled receptor; alpha-1C adrenergic receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; adrenergic, alpha-1A-, receptor variant 11
UniProt Protein Name
Alpha-1A adrenergic receptor
UniProt Synonym Protein Names
Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c
UniProt Gene Name
ADRA1A  [Similar Products]
UniProt Synonym Gene Names
ADRA1C; Alpha-1A adrenoceptor  [Similar Products]
UniProt Entry Name
ADA1A_HUMAN
NCBI Summary for ADRA1A
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRA1A
ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; nucleus; Z disc

Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: apoptosis; response to hormone stimulus; positive regulation of systemic arterial blood pressure; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; signal transduction; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; smooth muscle contraction; cell-cell signaling; positive regulation of MAPKKK cascade; positive regulation of action potential; positive regulation of smooth muscle contraction; cell growth; aging; adult heart development; response to drug; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of synaptic transmission, GABAergic; micturition; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; organ growth; G-protein coupled receptor protein signaling pathway; negative regulation of Rho protein signal transduction; phospholipase C activation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of heart rate by epinephrine-norepinephrine
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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